NCOA4 (Nuclear Receptor Coactivator 4) gene: Two isoforms: - Isoform alfa (614 aa, mass around 70kD) - Isoform beta: missing of aa 239-565 (mass around 32kD) NCOA4 is widely expressed in several tissues, including testis, adrenal and thyroid glands, thymus, prostate. A truncated NCOA4 corresponding to the beta isoform is fused to RET exon 12 and is aberrantly expressed in papillary thyroid carcinoma as a consequence of intrachromosomal rearrangements at 10q11.2 (RET/NCOA4). L'intero contributo trasferito in MSWord occupa 8 pagine.
deBiase D., Morandi L., Tallini G. (2008). NCOA4 (Nuclear Receptor Coactivator 4) gene.. POITIERS : Dept Medical Information, University Hospital.
NCOA4 (Nuclear Receptor Coactivator 4) gene.
DE BIASE, DARIO;MORANDI, LUCA;TALLINI, GIOVANNI
2008
Abstract
NCOA4 (Nuclear Receptor Coactivator 4) gene: Two isoforms: - Isoform alfa (614 aa, mass around 70kD) - Isoform beta: missing of aa 239-565 (mass around 32kD) NCOA4 is widely expressed in several tissues, including testis, adrenal and thyroid glands, thymus, prostate. A truncated NCOA4 corresponding to the beta isoform is fused to RET exon 12 and is aberrantly expressed in papillary thyroid carcinoma as a consequence of intrachromosomal rearrangements at 10q11.2 (RET/NCOA4). L'intero contributo trasferito in MSWord occupa 8 pagine.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
