Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta, and a poorly crystalline form named rifaximin gamma, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
VISCOMI G. C., CAMPANA M., BRAGA D., CONFORTINI D., CANNATA V., RIGHI P., et al. (2008). PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN.
PROCESSES FOR THE PRODUCTION OF POLYMORPHIC FORMS OF RIFAXIMIN
BRAGA, DARIO;RIGHI, PAOLO;ROSINI, GOFFREDO
2008
Abstract
Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin alpha and rifaximin beta, and a poorly crystalline form named rifaximin gamma, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
