Phosphatidylinositol Turnover and Receptors

Abstract Phosphoinositides are a small portion of cellular phospholipids involved in virtually all cellular processes. They play a fundamental role in cellular signaling pathways, membrane trafficking, actin cytoskeletal dynamics, and regulate ion channels and transporters. Multiple pathways including phosphoinositide kinases and phosphatases control tightly the turnover of phosphoinositides, therefore their membrane concentration and distribution. Many human diseases, including cancer, metabolic syndrome, and neurological diseases are caused by alteration in phosphoinositide dependent pathways, indicating that phosphoinositide metabolism is essential for the regulation a variety of physiological functions