Cancer immunoprevention, a recent development of tumor immunology based on vaccines and other immunological maneuvers to actively reduce the risk of cancer development, will greatly benefit from immunomic approaches for its progress in basic research and for its translation to human applications. The main approaches discussed in this chapter are the use of genetically-modified mouse models, microarray studies and data mining approaches to define antitumor immune responses and to discover new oncoantigens, and agent-based mathematical models to simulate tumor-immune system interactions and to perfect vaccination protocols.
Translational immunomics of cancer prevention.
NICOLETTI, GIORDANO;PALLADINI, ARIANNA;MURGO, ANNALISA;ANTOGNOLI, AGNESE;CROCI, STEFANIA;LOLLINI, PIER LUIGI
2009
Abstract
Cancer immunoprevention, a recent development of tumor immunology based on vaccines and other immunological maneuvers to actively reduce the risk of cancer development, will greatly benefit from immunomic approaches for its progress in basic research and for its translation to human applications. The main approaches discussed in this chapter are the use of genetically-modified mouse models, microarray studies and data mining approaches to define antitumor immune responses and to discover new oncoantigens, and agent-based mathematical models to simulate tumor-immune system interactions and to perfect vaccination protocols.File in questo prodotto:
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