With the aim of obtaining new molecules that could form nanomaterials through intermolecular aggregations in the solid state, we prepared some oligomers of the Boc-(L-Phe-D-Oxd)n-OR series with the expectation that the presence of phenyl groups could favour aggregation by means of NH hydrogen bonds and/or pi-stacking interactions. We can show that fibers or fibrils are formed dependent on the length of the foldamer chain. The chemical properties of these compounds have been examined in the solid phase utilizing X-ray diffraction, solid state NMR, SEM, and TEM microscopy. Theoretical calculations have been performed to explain the results.

AMYLOIDS: SELF-ASSEMBLY OF OXAZOLIDIN-2-ONES CONTAINING HYBRID PSEUDOPEPTIDES

ANGELICI, GAETANO;FALINI, GIUSEPPE;MONARI, MAGDA;TOMASINI, CLAUDIA
2008

Abstract

With the aim of obtaining new molecules that could form nanomaterials through intermolecular aggregations in the solid state, we prepared some oligomers of the Boc-(L-Phe-D-Oxd)n-OR series with the expectation that the presence of phenyl groups could favour aggregation by means of NH hydrogen bonds and/or pi-stacking interactions. We can show that fibers or fibrils are formed dependent on the length of the foldamer chain. The chemical properties of these compounds have been examined in the solid phase utilizing X-ray diffraction, solid state NMR, SEM, and TEM microscopy. Theoretical calculations have been performed to explain the results.
Proceedings of 2nd European Chemistry Congress
652
652
G. Angelici; G. Falini; H.-J. Hofmann; D. Huster; M. Monari; C. Tomasini
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/68115
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact