Topiramate analysis is difficult due to the lack of chromophores in its chemical structure and, consequently, its extremely low absorbance. This analytical problem has been solved developing an original derivatisation procedure to generate a fluorescent adduct, which has good fluorescence emission intensity and thus can be detected by HPLC with spectrofluorimetric detection. Preliminary results are satisfactory and method validation is in progress

Plasma analysis of topiramate by HPLC-F and precolumn derivatisation

MERCOLINI, LAURA;GHEDINI, NADIA;RAGGI, MARIA AUGUSTA
2008

Abstract

Topiramate analysis is difficult due to the lack of chromophores in its chemical structure and, consequently, its extremely low absorbance. This analytical problem has been solved developing an original derivatisation procedure to generate a fluorescent adduct, which has good fluorescence emission intensity and thus can be detected by HPLC with spectrofluorimetric detection. Preliminary results are satisfactory and method validation is in progress
Therapeutic and Toxic Effects of Central Nervous System Drugs: the Importance of Drug Monitoring
107
108
Mercolini L.; Paciotti C.; Lateana D.; Ghedini N.; Koukopoulos A.; Raggi M.A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/68079
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