Advances in multidrug delivery from electrospun nanomaterials

Multidrug delivery systems are attracting increasing interest nowadays given their great potential as a novel therapeutic combination for different diseases, including cancer. Many different approaches have been explored to create a library of multidrug systems with controlled release kinetics, able to fulfill most medical demands. In this context electrospinning, due to its versatility, represents a valuable technique to load multiple active agents into polymeric nano-microfibers. A broad range of synthetic and natural polymers can be processed into electrospun fibers, allowing the development of drug delivery systems with a broad spectrum of different chemical and physical properties. In this chapter three main methods, (1) monolithic electrospun fibers, (2) core-sheath fibers, and (3) electrospun fibers loaded with nanocarriers, will be discussed in detail, underlining the pros and cons of each technique and discussing the most representative examples reported in literature.