1,3-Dipolar cycloadditions of nitrile imines with functionalised acetylenes and α,β-unsaturated systems of various sizes have been studied. After cycloaddition, mono- and ring-fused pyrazoles have been obtained. Computational studies allowed a theoretical description of the observed reactivity, in agreement with the experimentally observed regio-chemistry. Selected targeted structures for medicinal applications have been synthetized and in vitro cytotoxicity showed that these pyrazoles can be considered powerful lead compounds for further medicinally relevant targets development.

Bertuzzi, G., Fochi, M., Franchini, M.C. (2016). Regiocontrolled 1,3-Dipolar cycloadditions of nitrile imines with acetylenes and α,β-unsaturated systems: Synthesis of polysubstituted and ring fused pyrazoles with pharmaceutical activity. Urbino (PU) : Societa Chimica Italiana [10.17374/targets.2017.20.337].

Regiocontrolled 1,3-Dipolar cycloadditions of nitrile imines with acetylenes and α,β-unsaturated systems: Synthesis of polysubstituted and ring fused pyrazoles with pharmaceutical activity

Bertuzzi, Giulio;Fochi, Mariafrancesca;Franchini, Mauro Comes
2016

Abstract

1,3-Dipolar cycloadditions of nitrile imines with functionalised acetylenes and α,β-unsaturated systems of various sizes have been studied. After cycloaddition, mono- and ring-fused pyrazoles have been obtained. Computational studies allowed a theoretical description of the observed reactivity, in agreement with the experimentally observed regio-chemistry. Selected targeted structures for medicinal applications have been synthetized and in vitro cytotoxicity showed that these pyrazoles can be considered powerful lead compounds for further medicinally relevant targets development.
2016
Targets in Heterocyclic Systems
337
364
Bertuzzi, G., Fochi, M., Franchini, M.C. (2016). Regiocontrolled 1,3-Dipolar cycloadditions of nitrile imines with acetylenes and α,β-unsaturated systems: Synthesis of polysubstituted and ring fused pyrazoles with pharmaceutical activity. Urbino (PU) : Societa Chimica Italiana [10.17374/targets.2017.20.337].
Bertuzzi, Giulio; Fochi, Mariafrancesca; Franchini, Mauro Comes*
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/663197
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