1,3-Dipolar cycloadditions of nitrile imines with functionalised acetylenes and α,β-unsaturated systems of various sizes have been studied. After cycloaddition, mono- and ring-fused pyrazoles have been obtained. Computational studies allowed a theoretical description of the observed reactivity, in agreement with the experimentally observed regio-chemistry. Selected targeted structures for medicinal applications have been synthetized and in vitro cytotoxicity showed that these pyrazoles can be considered powerful lead compounds for further medicinally relevant targets development.
Bertuzzi, G., Fochi, M., Franchini, M.C. (2016). Regiocontrolled 1,3-Dipolar cycloadditions of nitrile imines with acetylenes and α,β-unsaturated systems: Synthesis of polysubstituted and ring fused pyrazoles with pharmaceutical activity. Urbino (PU) : Societa Chimica Italiana [10.17374/targets.2017.20.337].
Regiocontrolled 1,3-Dipolar cycloadditions of nitrile imines with acetylenes and α,β-unsaturated systems: Synthesis of polysubstituted and ring fused pyrazoles with pharmaceutical activity
Bertuzzi, Giulio;Fochi, Mariafrancesca;Franchini, Mauro Comes
2016
Abstract
1,3-Dipolar cycloadditions of nitrile imines with functionalised acetylenes and α,β-unsaturated systems of various sizes have been studied. After cycloaddition, mono- and ring-fused pyrazoles have been obtained. Computational studies allowed a theoretical description of the observed reactivity, in agreement with the experimentally observed regio-chemistry. Selected targeted structures for medicinal applications have been synthetized and in vitro cytotoxicity showed that these pyrazoles can be considered powerful lead compounds for further medicinally relevant targets development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.