Recent advances in the application of molecular rotational spectroscopy to chiral analysis are described. These include the use of broadband rotational spectroscopy for the analysis of diastereomers of molecules with multiple chiral centers. Two new approaches to enantiomer-specific rotational spectroscopy are presented. One method adapts strategies from nuclear magnetic resonance spectroscopy by using noncovalent attachment of a chiral tag molecule to convert enantiomers into diastereomers. Applications of this method to the high-confidence determination of absolute stereochemistry and the measurement of the enantiomeric excess without reference samples of the analyte are illustrated with recent measurements. The second approach is a novel three-wave mixing method that generates a phase-dependent chiral emission signal. This method offers the possibility for direct chiral analysis of molecules in complex chemical mixtures without the need for chemical separation protocol development.
Pate, B.H., Evangelisti, L., Caminati, W., Xu, Y., Thomas, J., Patterson, D., et al. (2018). Quantitative chiral analysis by molecular rotational spectroscopy. Amsterdam : Elsevier Inc. [10.1016/B978-0-444-64027-7.00019-7].
Quantitative chiral analysis by molecular rotational spectroscopy
Evangelisti, Luca;Caminati, Walther;
2018
Abstract
Recent advances in the application of molecular rotational spectroscopy to chiral analysis are described. These include the use of broadband rotational spectroscopy for the analysis of diastereomers of molecules with multiple chiral centers. Two new approaches to enantiomer-specific rotational spectroscopy are presented. One method adapts strategies from nuclear magnetic resonance spectroscopy by using noncovalent attachment of a chiral tag molecule to convert enantiomers into diastereomers. Applications of this method to the high-confidence determination of absolute stereochemistry and the measurement of the enantiomeric excess without reference samples of the analyte are illustrated with recent measurements. The second approach is a novel three-wave mixing method that generates a phase-dependent chiral emission signal. This method offers the possibility for direct chiral analysis of molecules in complex chemical mixtures without the need for chemical separation protocol development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
