Orthotopic liver transplantation (OLT) has been established as the definitive therapy for all types of end-stage liver failure. In spite of the steady improvement in survival of OLT recipients over the past two decades, a proportion of those patients experience graft failure and require retransplantation (re-OLT). Over the last 10 years, the reported waitlist admission for re-OLT varied between 5.5 and 14 % [1–3]. Re-OLT indications can be divided into “early” and “late” causes. Causes of early graft failure are: • Primary non-function (PNF) • Vascular complications (hepatic artery thrombosis, portal thrombosis, hepatic vein thrombosis) • Acute rejection Causes of late graft failure include: • Recurrence of liver disease (viral infection, autoimmune diseases) • Chronic rejection
Bertuzzo, V.R., Ercolani, G., Cescon, M., Pinna, A.D. (2015). Retransplantation (causes, outcome). Zurigo : Springer International Publishing [10.1007/978-3-319-16997-2_14].
Retransplantation (causes, outcome)
Bertuzzo, Valentina Rosa;Ercolani, Giorgio;Cescon, Matteo;Pinna, Antonio Daniele
2015
Abstract
Orthotopic liver transplantation (OLT) has been established as the definitive therapy for all types of end-stage liver failure. In spite of the steady improvement in survival of OLT recipients over the past two decades, a proportion of those patients experience graft failure and require retransplantation (re-OLT). Over the last 10 years, the reported waitlist admission for re-OLT varied between 5.5 and 14 % [1–3]. Re-OLT indications can be divided into “early” and “late” causes. Causes of early graft failure are: • Primary non-function (PNF) • Vascular complications (hepatic artery thrombosis, portal thrombosis, hepatic vein thrombosis) • Acute rejection Causes of late graft failure include: • Recurrence of liver disease (viral infection, autoimmune diseases) • Chronic rejectionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
