Orthotopic liver transplantation (OLT) has been established as the definitive therapy for all types of end-stage liver failure. In spite of the steady improvement in survival of OLT recipients over the past two decades, a proportion of those patients experience graft failure and require retransplantation (re-OLT). Over the last 10 years, the reported waitlist admission for re-OLT varied between 5.5 and 14 % [1–3]. Re-OLT indications can be divided into “early” and “late” causes. Causes of early graft failure are: • Primary non-function (PNF) • Vascular complications (hepatic artery thrombosis, portal thrombosis, hepatic vein thrombosis) • Acute rejection Causes of late graft failure include: • Recurrence of liver disease (viral infection, autoimmune diseases) • Chronic rejection

Retransplantation (causes, outcome)

Bertuzzo, Valentina Rosa;Ercolani, Giorgio;Cescon, Matteo;Pinna, Antonio Daniele
2015

Abstract

Orthotopic liver transplantation (OLT) has been established as the definitive therapy for all types of end-stage liver failure. In spite of the steady improvement in survival of OLT recipients over the past two decades, a proportion of those patients experience graft failure and require retransplantation (re-OLT). Over the last 10 years, the reported waitlist admission for re-OLT varied between 5.5 and 14 % [1–3]. Re-OLT indications can be divided into “early” and “late” causes. Causes of early graft failure are: • Primary non-function (PNF) • Vascular complications (hepatic artery thrombosis, portal thrombosis, hepatic vein thrombosis) • Acute rejection Causes of late graft failure include: • Recurrence of liver disease (viral infection, autoimmune diseases) • Chronic rejection
2015
Abdominal Solid Organ Transplantation: Immunology, Indications, Techniques, and Early Complications
231
241
Bertuzzo, Valentina Rosa*; Ercolani, Giorgio; Cescon, Matteo; Pinna, Antonio Daniele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/655626
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