Transcripts for sweet and bitter taste receptors and the gustatory G proteins, α-gustducin and α-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of α-transducin in the pig GI tract; 2) type of cells expressing α-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between α-transducin cells and enteric nerves. The presence of α-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).
CLAVENZANI P., DE GIORGIO R., MAZZONI M., CHIOCCHETTI R., BARBARA G., LALATTA COSTERBOSA G., et al. (2008). Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.. Messina : Sinergia arti grafiche e visive.
Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.
CLAVENZANI, PAOLO;DE GIORGIO, ROBERTO;MAZZONI, MAURIZIO;CHIOCCHETTI, ROBERTO;BARBARA, GIOVANNI;LALATTA COSTERBOSA, GIOVANNA;
2008
Abstract
Transcripts for sweet and bitter taste receptors and the gustatory G proteins, α-gustducin and α-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of α-transducin in the pig GI tract; 2) type of cells expressing α-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between α-transducin cells and enteric nerves. The presence of α-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
