Transcripts for sweet and bitter taste receptors and the gustatory G proteins, α-gustducin and α-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of α-transducin in the pig GI tract; 2) type of cells expressing α-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between α-transducin cells and enteric nerves. The presence of α-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).
Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino / CLAVENZANI P.; DE GIORGIO R.; MAZZONI M.; CHIOCCHETTI R.; BARBARA G.; LALATTA COSTERBOSA G.; RUSSO D.; STERNINI C.. - ELETTRONICO. - LXII:(2008), pp. 5-6. (Intervento presentato al convegno LXII Convegno Nazionale della Società Italiana delle Scienze Veterinarie tenutosi a S. Benedetto del Tronto nel 24-26 settembre 2008).
Espressione dell’ α-transducina, una molecola della chemorecezione, in cellule endocrine e non endocrine del tratto gastrointestinale di suino.
CLAVENZANI, PAOLO;DE GIORGIO, ROBERTO;MAZZONI, MAURIZIO;CHIOCCHETTI, ROBERTO;BARBARA, GIOVANNI;LALATTA COSTERBOSA, GIOVANNA;
2008
Abstract
Transcripts for sweet and bitter taste receptors and the gustatory G proteins, α-gustducin and α-transducin, are expressed by the oral cavity and the gastrointestinal (GI) mucosa. This study evaluated: 1) distribution of α-transducin in the pig GI tract; 2) type of cells expressing α-transducin (chromogranin-A, gastrin/cholecystokinin, somatostatin, villin) 3) relationship between α-transducin cells and enteric nerves. The presence of α-transducin-IR in enteroendocrine cells supports an active chemosensory machinery in the GI mucosa and that taste signalling molecules contribute to luminal chemosensing. These mechanisms may occur via neuro-endocrine cross-talk activating digestive or protective reflex pathways (e.g. vomiting or food aversion).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
