The 5-HT2A receptor type (5-HT2AR) is a G-protein-coupled receptor widely distributed in the central nervous system, indicating its participation in numerous neurological effects serotonin-mediated. The 5-HT2AR has attracted interest as a potential drug target for the treatment of several important neurologic and psychiatric disorders, such as epilepsy and depression. The distribution of the 5-HT2AR has been investigated by immunohistochemical stainings, in situ hybridization experiments, and physiologic/pharmacologic procedures. This review summarizes the cellular localization of the 5-HT2AR in the brains, providing the neuronal pathways modulated by serotonin trought this specific receptor type.

Bombardi, C. (2018). Brain Distribution. In: B.P. Guiard, G. Di Giovanni Editors. 5-HT2A receptors in the Central Nervous System. Humana Press Springer. Chatenay-Malabry, France; Msida MSD, Malta : B.P. Guiard, G. Di Giovanni [10.1007/978-3-319-70474-6_4].

Brain Distribution. In: B.P. Guiard, G. Di Giovanni Editors. 5-HT2A receptors in the Central Nervous System. Humana Press Springer

Bombardi, Cristiano
2018

Abstract

The 5-HT2A receptor type (5-HT2AR) is a G-protein-coupled receptor widely distributed in the central nervous system, indicating its participation in numerous neurological effects serotonin-mediated. The 5-HT2AR has attracted interest as a potential drug target for the treatment of several important neurologic and psychiatric disorders, such as epilepsy and depression. The distribution of the 5-HT2AR has been investigated by immunohistochemical stainings, in situ hybridization experiments, and physiologic/pharmacologic procedures. This review summarizes the cellular localization of the 5-HT2AR in the brains, providing the neuronal pathways modulated by serotonin trought this specific receptor type.
2018
18
978-3-319-70472-2
978-3-319-70474-6
Bombardi, C. (2018). Brain Distribution. In: B.P. Guiard, G. Di Giovanni Editors. 5-HT2A receptors in the Central Nervous System. Humana Press Springer. Chatenay-Malabry, France; Msida MSD, Malta : B.P. Guiard, G. Di Giovanni [10.1007/978-3-319-70474-6_4].
Bombardi, Cristiano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/632452
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