The 5-HT2A receptor type (5-HT2AR) is a G-protein-coupled receptor widely distributed in the central nervous system, indicating its participation in numerous neurological effects serotonin-mediated. The 5-HT2AR has attracted interest as a potential drug target for the treatment of several important neurologic and psychiatric disorders, such as epilepsy and depression. The distribution of the 5-HT2AR has been investigated by immunohistochemical stainings, in situ hybridization experiments, and physiologic/pharmacologic procedures. This review summarizes the cellular localization of the 5-HT2AR in the brains, providing the neuronal pathways modulated by serotonin trought this specific receptor type.
Brain Distribution. In: B.P. Guiard, G. Di Giovanni Editors. 5-HT2A receptors in the Central Nervous System. Humana Press Springer / Bombardi, Cristiano. - STAMPA. - (2018), pp. 67-84. [10.1007/978-3-319-70474-6_4]
Brain Distribution. In: B.P. Guiard, G. Di Giovanni Editors. 5-HT2A receptors in the Central Nervous System. Humana Press Springer
Bombardi, Cristiano
2018
Abstract
The 5-HT2A receptor type (5-HT2AR) is a G-protein-coupled receptor widely distributed in the central nervous system, indicating its participation in numerous neurological effects serotonin-mediated. The 5-HT2AR has attracted interest as a potential drug target for the treatment of several important neurologic and psychiatric disorders, such as epilepsy and depression. The distribution of the 5-HT2AR has been investigated by immunohistochemical stainings, in situ hybridization experiments, and physiologic/pharmacologic procedures. This review summarizes the cellular localization of the 5-HT2AR in the brains, providing the neuronal pathways modulated by serotonin trought this specific receptor type.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
