Urine is an ideal biological sample. It is an important source of clinical biomarkers of systemic and renal diseases and can be obtained repeatedly without causing stress. Different analytical protocols for the study of the urine proteome have been used, from the simplest electrophoresis on agarose gels to the most sensitive and complex 2DE. As with urine, a range of bodily fluids (saliva, cerebrospinal, bronchoalveolar, amniotic fluids) are amenable to the tools of proteomics. The identification and characterization of the protein content of such fluids are being used to provide novel insights into the evolutionary adaptations of farm and domestic animal species and to characterize their normal physiological state. A comprehensive review on the application of proteomics to these biological samples is presented.
Proteomic Research in Urine and Other Fluids / Gloria Isani, Enea Ferlizza, Jarlath E. Nally. - STAMPA. - (2018), pp. 121-147. [10.1007/978-3-319-69682-9_7]
Proteomic Research in Urine and Other Fluids
Gloria Isani;Enea Ferlizza;
2018
Abstract
Urine is an ideal biological sample. It is an important source of clinical biomarkers of systemic and renal diseases and can be obtained repeatedly without causing stress. Different analytical protocols for the study of the urine proteome have been used, from the simplest electrophoresis on agarose gels to the most sensitive and complex 2DE. As with urine, a range of bodily fluids (saliva, cerebrospinal, bronchoalveolar, amniotic fluids) are amenable to the tools of proteomics. The identification and characterization of the protein content of such fluids are being used to provide novel insights into the evolutionary adaptations of farm and domestic animal species and to characterize their normal physiological state. A comprehensive review on the application of proteomics to these biological samples is presented.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
