Respiratory Supercomplexes in Mitochondria

Table of contents 12.1. INTRODUCTION 12.1.1. The respiratory chain of mitochondria 12.1.2. Organization of the respiratory chain: historical outline 12.2. DISTRIBUTION AND COMPOSITION OF RESPIRATORY SUPERCOMPLEXES 12.2.1. Distribution in different organisms 12.2.2. Composition of respiratory supercomplexes 12.3. SUPERCOMPLEX ASSOCIATION PROVIDES A KINETIC ADVANTAGE 12.3.1. Structural evidence 12.3.1.1. Molecular structure of supercomplexes 12.3.1.2. Dynamic nature of supercomplexes: the plasticity model 12.3.1.3. The role of lipids: cardiolipin in supercomplexes 12.3.1.4. Standing uncertainties 12.3.2. Evidence for channelling in the Coenzyme Q region 12.3.2.1. Rate advantage in the Coenzyme Q region 12.3.2.2. Evidence for channelling by metabolic flux control analysis 12.3.2.3. Separate compartments of Coenzyme Q? 12.3.2.4. The function of the Coenzyme Q pool 12.3.2.4.1. Dissociation equilibrium of bound Coenzyme Q 12.3.2.4.2. Electron transfer between individual complexes not involved in supercomplex organization 12.3.2.5. Concluding evidence about channelling in the Coenzyme Q region 12.3.3. Electron transfer through cytochrome c 12.4. SUPERCOMPLEXES AND REACTIVE OXYGEN SPECIES 12.5. PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS 12.5.1. Supercomplexes and regulation of metabolic fluxes 12.5.2. Supercomplexes and ROS signalling 12.5.3. Supercomplexes in pathology and aging