Table of contents 12.1. INTRODUCTION 12.1.1. The respiratory chain of mitochondria 12.1.2. Organization of the respiratory chain: historical outline 12.2. DISTRIBUTION AND COMPOSITION OF RESPIRATORY SUPERCOMPLEXES 12.2.1. Distribution in different organisms 12.2.2. Composition of respiratory supercomplexes 12.3. SUPERCOMPLEX ASSOCIATION PROVIDES A KINETIC ADVANTAGE 12.3.1. Structural evidence 12.3.1.1. Molecular structure of supercomplexes 12.3.1.2. Dynamic nature of supercomplexes: the plasticity model 12.3.1.3. The role of lipids: cardiolipin in supercomplexes 12.3.1.4. Standing uncertainties 12.3.2. Evidence for channelling in the Coenzyme Q region 12.3.2.1. Rate advantage in the Coenzyme Q region 12.3.2.2. Evidence for channelling by metabolic flux control analysis 12.3.2.3. Separate compartments of Coenzyme Q? 12.3.2.4. The function of the Coenzyme Q pool 12.3.2.4.1. Dissociation equilibrium of bound Coenzyme Q 12.3.2.4.2. Electron transfer between individual complexes not involved in supercomplex organization 12.3.2.5. Concluding evidence about channelling in the Coenzyme Q region 12.3.3. Electron transfer through cytochrome c 12.4. SUPERCOMPLEXES AND REACTIVE OXYGEN SPECIES 12.5. PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS 12.5.1. Supercomplexes and regulation of metabolic fluxes 12.5.2. Supercomplexes and ROS signalling 12.5.3. Supercomplexes in pathology and aging

Respiratory Supercomplexes in Mitochondria

Giorgio Lenaz
Writing – Original Draft Preparation
;
Gaia Tioli
Data Curation
;
Maria Luisa Genova
Writing – Original Draft Preparation
2017

Abstract

Table of contents 12.1. INTRODUCTION 12.1.1. The respiratory chain of mitochondria 12.1.2. Organization of the respiratory chain: historical outline 12.2. DISTRIBUTION AND COMPOSITION OF RESPIRATORY SUPERCOMPLEXES 12.2.1. Distribution in different organisms 12.2.2. Composition of respiratory supercomplexes 12.3. SUPERCOMPLEX ASSOCIATION PROVIDES A KINETIC ADVANTAGE 12.3.1. Structural evidence 12.3.1.1. Molecular structure of supercomplexes 12.3.1.2. Dynamic nature of supercomplexes: the plasticity model 12.3.1.3. The role of lipids: cardiolipin in supercomplexes 12.3.1.4. Standing uncertainties 12.3.2. Evidence for channelling in the Coenzyme Q region 12.3.2.1. Rate advantage in the Coenzyme Q region 12.3.2.2. Evidence for channelling by metabolic flux control analysis 12.3.2.3. Separate compartments of Coenzyme Q? 12.3.2.4. The function of the Coenzyme Q pool 12.3.2.4.1. Dissociation equilibrium of bound Coenzyme Q 12.3.2.4.2. Electron transfer between individual complexes not involved in supercomplex organization 12.3.2.5. Concluding evidence about channelling in the Coenzyme Q region 12.3.3. Electron transfer through cytochrome c 12.4. SUPERCOMPLEXES AND REACTIVE OXYGEN SPECIES 12.5. PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS 12.5.1. Supercomplexes and regulation of metabolic fluxes 12.5.2. Supercomplexes and ROS signalling 12.5.3. Supercomplexes in pathology and aging
Mechanisms of Primary Energy Transduction in Biology
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337
Giorgio Lenaz, Gaia Tioli, Anna Ida Falasca, Maria Luisa Genova
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/626109
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