BIOMECHANICAL SIMULATION OF THE LEFT VENTRICLE IN HF AND BIVENTRICULAR RESYNCHRONISATION

Reduced ejection fraction in Heart failure (HF) is caused by the mechanical dyssynchrony in contraction timing. Cardiac resynchronisation therapy (CRT) is used to treat the discoordinate ventricle wall motion. One of the problems we try to solve is whether the dyssynchrony in left ventricle contraction is the heart’s attempt to increase the ejection fraction or simply an electrical conductivity problem of the heart. Moreover we tried to find out why CRT produces an improvement in patients’ conditions. To do this we developed a mechanical simulator equipped to change the contraction timing and contractility function of the septal and posterior ventricular walls.