In the last years polyhydroxyalkanoates (PHAs) gained increasing attention as potential sustainable replacement of current plastics from fossil sources. PHAs are biodegradable polymers which can be produced from bacteria exploiting waste as feedstock. In order to bring these polymers on the market, it is necessary to know their properties and assess the effects of industrial processing stages on the final material. For this reason, in this work different industrial PHAs were investigated. These materials were structurally characterized and their thermal properties were assessed. Furthermore, they were subjected to different thermal and thermo—mechanical treatments (various time, temperature and frequency of rotation in the extruder) in order to study the effect of the applied conditions on the properties of the final material.