The experiment is a simple and practical organocatalytic procedure for the enantiose- lective alkylation of aldehydes using a commercially available and stable carbenium ion. The alkylated adduct 4, obtained in high enantiomeric excess, is then transformed into the corresponding enantioen- riched alcohol 5 by reduction of the benzodithiole group with Raney®-nickel.
Pier Giorgio, C., Marco, B., Andrea, G., Luca, M. (2016). A Practical Organocatalytic Alkylation Reaction with Benzodithiolylium Tetrafluoroborate. Cambridge : The Royal Society of Chemistry.
A Practical Organocatalytic Alkylation Reaction with Benzodithiolylium Tetrafluoroborate
COZZI, PIER GIORGIO;BANDINI, MARCO;GUALANDI, ANDREA;MENGOZZI, LUCA
2016
Abstract
The experiment is a simple and practical organocatalytic procedure for the enantiose- lective alkylation of aldehydes using a commercially available and stable carbenium ion. The alkylated adduct 4, obtained in high enantiomeric excess, is then transformed into the corresponding enantioen- riched alcohol 5 by reduction of the benzodithiole group with Raney®-nickel.File in questo prodotto:
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