The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer. In this context, the interest is currently focused toward the study of certain diet-derived molecules to prevent, delay, or treat cancer by acting simultaneously on different critical pathways. Among phytochemicals, sulforaphane, an isothiocyanate derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, is one of the most promising diet-derived molecules. In this chapter, we will present the antileukemic activity of sulforaphane and discuss its therapeutic potential in terms of mechanisms of action, safety, and limits.

Antileukemic Activity of Sulforaphane

CATANZARO, ELENA;FIMOGNARI, CARMELA
2016

Abstract

The biological complexity of cancer offers numerous targets for antineoplastic therapies. Diet is a common source of biologically active compounds. Many studies demonstrated an inverse relation between the consumption of vegetables and the risk of cancer. In this context, the interest is currently focused toward the study of certain diet-derived molecules to prevent, delay, or treat cancer by acting simultaneously on different critical pathways. Among phytochemicals, sulforaphane, an isothiocyanate derived from the hydrolysis of the glucosinolate glucoraphanin mainly present in Brassica vegetables, is one of the most promising diet-derived molecules. In this chapter, we will present the antileukemic activity of sulforaphane and discuss its therapeutic potential in terms of mechanisms of action, safety, and limits.
Glucosinolates Reference Series in Phytochemistry
1
17
Catanzaro, E; Fimognari, C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/585554
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