Recently, several examples of foldamers have been reported containing a mixture of alpha,beta-amino acids in alternating order. In several cases, an increased resistance of the pseudopeptides against proteases was indicated in comparison to their native counterparts. Here, we report on the synthesis of novel foldamers with the general formula Boc-[(S)-beta3-hPhg-D-Oxd]n-OR, where (S)-beta3-hPhg is the abbreviation for (S)-beta3-homophenylglycine and D-Oxd that for trans-(4R,5S) 4-carboxy-5-methyl oxazolidin-2-one.
Synthesis an Secondary Structure of Alternate alpha,beta-Hybrid Peptides Containing Oxazolidin-2-one Moieties / G. Angelici; C. Tomasini. - STAMPA. - (2007), pp. PF1-PF1. (Intervento presentato al convegno XXXI Convegno Nazionale della Divisione di Chimica Organica della Società di Chimica Italiana tenutosi a Università della Calabria, Rende nel 10-14 Settembre 2007).
Synthesis an Secondary Structure of Alternate alpha,beta-Hybrid Peptides Containing Oxazolidin-2-one Moieties
ANGELICI, GAETANO;TOMASINI, CLAUDIA
2007
Abstract
Recently, several examples of foldamers have been reported containing a mixture of alpha,beta-amino acids in alternating order. In several cases, an increased resistance of the pseudopeptides against proteases was indicated in comparison to their native counterparts. Here, we report on the synthesis of novel foldamers with the general formula Boc-[(S)-beta3-hPhg-D-Oxd]n-OR, where (S)-beta3-hPhg is the abbreviation for (S)-beta3-homophenylglycine and D-Oxd that for trans-(4R,5S) 4-carboxy-5-methyl oxazolidin-2-one.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
