Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.
Bonvicini, F., Giudice, A.M., Bua, G., Conti, I., Manaresi, E., Gallinella, G. (2016). Antiviral effect of Hydroxyurea on B19V replication.
Antiviral effect of Hydroxyurea on B19V replication
BONVICINI, FRANCESCA;Anna Maria Giudice;BUA, GLORIA;CONTI, ILARIA;MANARESI, ELISABETTA;GALLINELLA, GIORGIO
2016
Abstract
Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
