Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.
Antiviral effect of Hydroxyurea on B19V replication / Francesca Bonvicini; Anna Maria Giudice; Gloria Bua; Ilaria Conti; Elisabetta Manaresi; Giorgio Gallinella. - STAMPA. - (2016), pp. 34-34. (Intervento presentato al convegno XI CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI MICROBIOLOGIA FARMACEUTICA tenutosi a Bologna nel 9-10 Giugno 2016).
Antiviral effect of Hydroxyurea on B19V replication
BONVICINI, FRANCESCA;Anna Maria Giudice;BUA, GLORIA;CONTI, ILARIA;MANARESI, ELISABETTA;GALLINELLA, GIORGIO
2016
Abstract
Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
