Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.

Antiviral effect of Hydroxyurea on B19V replication

BONVICINI, FRANCESCA;Anna Maria Giudice;BUA, GLORIA;CONTI, ILARIA;MANARESI, ELISABETTA;GALLINELLA, GIORGIO
2016

Abstract

Parvovirus B19 (B19V), a human pathogenic ssDNA virus in the Parvoviridae family, is characterized by a strict tropism towards erythroid progenitor cells in bone marrow. Infections commonly induce self-limiting clinical manifestations, as erythema infectiosum in children and arthropathies mainly in adults, but, in subjects with underlying hematological disorders or with immune system deficits, the viral-induced arrest of erythropoiesis can lead to severe clinical manifestations requiring hospitalization and supportive transfusion or passive immunization treatments.
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Francesca Bonvicini; Anna Maria Giudice; Gloria Bua; Ilaria Conti; Elisabetta Manaresi; Giorgio Gallinella
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/570687
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