CONTENTS 5.1 Introduction 5.2 Respiratory Supercomplexes: Structure and Function 5.2.1 Molecular Composition 5.2.2 Dynamic Nature and Kinetic Advantage of Supercomplexes 5.3 ROS Generation by Mitochondria 5.3.1 Respiratory Chain as a Source of ROS 5.3.1.1 Complex I 5.3.1.2 Complex III 5.3.1.3 Other Respiratory Enzymes 5.4 Mitochondrial ROS as Signals: Targets and Mechanisms 5.5 Regulation of Mitochondrial ROS Generation 5.5.1 Role of Mitochondrial Membrane Potential 5.5.2 Role of Post-Translational Modifications 5.5.3 Hypoxia and ROS Production 5.5.4 Role of Supercomplexes 5.6 ROS and Mitochondrial Quality Control 5.7 Implications for Ageing 5.7.1 Unifying Hypothesis Involving Supercomplex Destabilization in Ageing
Genova, M.L., Lenaz, G. (2015). Chapter 5. Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing. Boca Raton : CRC Press.
Chapter 5. Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing
GENOVA, MARIA LUISA;LENAZ, GIORGIO
2015
Abstract
CONTENTS 5.1 Introduction 5.2 Respiratory Supercomplexes: Structure and Function 5.2.1 Molecular Composition 5.2.2 Dynamic Nature and Kinetic Advantage of Supercomplexes 5.3 ROS Generation by Mitochondria 5.3.1 Respiratory Chain as a Source of ROS 5.3.1.1 Complex I 5.3.1.2 Complex III 5.3.1.3 Other Respiratory Enzymes 5.4 Mitochondrial ROS as Signals: Targets and Mechanisms 5.5 Regulation of Mitochondrial ROS Generation 5.5.1 Role of Mitochondrial Membrane Potential 5.5.2 Role of Post-Translational Modifications 5.5.3 Hypoxia and ROS Production 5.5.4 Role of Supercomplexes 5.6 ROS and Mitochondrial Quality Control 5.7 Implications for Ageing 5.7.1 Unifying Hypothesis Involving Supercomplex Destabilization in AgeingI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
