CONTENTS 5.1 Introduction 5.2 Respiratory Supercomplexes: Structure and Function 5.2.1 Molecular Composition 5.2.2 Dynamic Nature and Kinetic Advantage of Supercomplexes 5.3 ROS Generation by Mitochondria 5.3.1 Respiratory Chain as a Source of ROS 5.3.1.1 Complex I 5.3.1.2 Complex III 5.3.1.3 Other Respiratory Enzymes 5.4 Mitochondrial ROS as Signals: Targets and Mechanisms 5.5 Regulation of Mitochondrial ROS Generation 5.5.1 Role of Mitochondrial Membrane Potential 5.5.2 Role of Post-Translational Modifications 5.5.3 Hypoxia and ROS Production 5.5.4 Role of Supercomplexes 5.6 ROS and Mitochondrial Quality Control 5.7 Implications for Ageing 5.7.1 Unifying Hypothesis Involving Supercomplex Destabilization in Ageing

Chapter 5. Mitochondrial Supercomplexes and ROS Regulation: Implications for Ageing

GENOVA, MARIA LUISA;LENAZ, GIORGIO
2015

Abstract

CONTENTS 5.1 Introduction 5.2 Respiratory Supercomplexes: Structure and Function 5.2.1 Molecular Composition 5.2.2 Dynamic Nature and Kinetic Advantage of Supercomplexes 5.3 ROS Generation by Mitochondria 5.3.1 Respiratory Chain as a Source of ROS 5.3.1.1 Complex I 5.3.1.2 Complex III 5.3.1.3 Other Respiratory Enzymes 5.4 Mitochondrial ROS as Signals: Targets and Mechanisms 5.5 Regulation of Mitochondrial ROS Generation 5.5.1 Role of Mitochondrial Membrane Potential 5.5.2 Role of Post-Translational Modifications 5.5.3 Hypoxia and ROS Production 5.5.4 Role of Supercomplexes 5.6 ROS and Mitochondrial Quality Control 5.7 Implications for Ageing 5.7.1 Unifying Hypothesis Involving Supercomplex Destabilization in Ageing
Redox Proteins in Supercomplexes and Signalosomes
107
148
Genova, Maria Luisa; Lenaz, Giorgio
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/553235
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact