Drug interactions with voriconazole

Drug interactions are a potential problem with voriconazole therapy, due to the antifungal's extensive interaction with human cytochrome P450 enzymes and transporters. While some of these interactions can be severe and result in either undetectable bloodstream concentrations of voriconazole, or possibly toxic levels of the coadministered medication, most interactions can be anticipated and safely managed with the aid of computerized screening databases and therapeutic drug monitoring. In this chapter, we highlight common pharmacokinetic drug-drug interaction s that occur with voriconazole, and discuss strategies for their management.