Fruit and vegetables have traditionally represented a main source for the discovery of many biologically active substances with therapeutic values. Among the many bioactive compounds identified over the years, sulfur-containing compounds, which are present especially in the genera Allium and Brassica, have been showing a protective effect against different types of cancer. Many in vitro and in vivo studies reported that apoptosis is crucial for the anticancer effects of sulfur-containing compounds. Garlic and onion compounds and isothiocyanates contained in Brassica vegetables are able to modulate apoptosis by a wide range of mechanisms. This chapter will give an overview on the induction of apoptosis by sulfur-containing compounds in cancer cells and their different molecular mechanisms. Finally, the potential clinical implications of their proapoptotic effects will be discussed.

De Gianni, E., Fimognari, C. (2015). Anticancer Mechanism of Sulfur-Containing Compounds.. Waltham : Elsevier Academic Press [10.1016/bs.enz.2015.05.003].

Anticancer Mechanism of Sulfur-Containing Compounds.

DE GIANNI, ELENA;FIMOGNARI, CARMELA
2015

Abstract

Fruit and vegetables have traditionally represented a main source for the discovery of many biologically active substances with therapeutic values. Among the many bioactive compounds identified over the years, sulfur-containing compounds, which are present especially in the genera Allium and Brassica, have been showing a protective effect against different types of cancer. Many in vitro and in vivo studies reported that apoptosis is crucial for the anticancer effects of sulfur-containing compounds. Garlic and onion compounds and isothiocyanates contained in Brassica vegetables are able to modulate apoptosis by a wide range of mechanisms. This chapter will give an overview on the induction of apoptosis by sulfur-containing compounds in cancer cells and their different molecular mechanisms. Finally, the potential clinical implications of their proapoptotic effects will be discussed.
2015
Enzymes
167
192
De Gianni, E., Fimognari, C. (2015). Anticancer Mechanism of Sulfur-Containing Compounds.. Waltham : Elsevier Academic Press [10.1016/bs.enz.2015.05.003].
De Gianni, E; Fimognari, C.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/547996
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 24
  • ???jsp.display-item.citation.isi??? ND
social impact