Breast cancer is the leading cause of cancer death in women worldwide. Gene expression studies have been used over the last decades to defi ne the signature of different breast cancer subtypes and to predict outcome and response to therapies. Recently, microRNAs (miRNAs) have been linked to several human diseases, including cancer. An aberrant miRNA expression in breast cancer was fi rst reported in 2005. Now, an increasing body of experimental evidences supports the role of these small molecules in the tumorigenic process and their potential use as cancer specifi c biomarkers. Indeed, miRNAs are detectable as circulating molecules in the blood. In this chapter, we summarize our knowledge about the involvement of miRNAs in breast cancer and their potential as diagnostic, prognostic and therapeutic tools.

M. Ferracin, L. Lupini (2014). MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer. Switzerland : Springer International Publishing [10.1007/978-3-319-03725-7_14].

MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer

FERRACIN, MANUELA;
2014

Abstract

Breast cancer is the leading cause of cancer death in women worldwide. Gene expression studies have been used over the last decades to defi ne the signature of different breast cancer subtypes and to predict outcome and response to therapies. Recently, microRNAs (miRNAs) have been linked to several human diseases, including cancer. An aberrant miRNA expression in breast cancer was fi rst reported in 2005. Now, an increasing body of experimental evidences supports the role of these small molecules in the tumorigenic process and their potential use as cancer specifi c biomarkers. Indeed, miRNAs are detectable as circulating molecules in the blood. In this chapter, we summarize our knowledge about the involvement of miRNAs in breast cancer and their potential as diagnostic, prognostic and therapeutic tools.
2014
MicroRNAs: Key Regulators of Oncogenesis
355
367
M. Ferracin, L. Lupini (2014). MicroRNA Expression Profiling and Its Clinical Impact in Breast Cancer. Switzerland : Springer International Publishing [10.1007/978-3-319-03725-7_14].
M. Ferracin; L. Lupini
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/542228
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? ND
social impact