Chemokines play an important role in orchestrating leukocyte recruitment and activation during inflammation. Given the ubiquity of chemokines involved in inflammatory tissue destruction, it is not surprising that they contribute to numerous human pathologies. Epidemiological studies have suggested that chronic low-grade inflammation is related to several diseases of ageing with an inflammatory pathogenesis (such as artherosclerosis, type 2 diabetes, osteoarthritis and Alzheimer's disease) and to increased mortality risk. In this chapter, we will briefly review the properties of chemokines ad their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.
Mariani E., Mariani A.R., Facchini A. (2007). Role of chemokines and chemokine receptors in diseases of ageing.. AUSTIN, TX : Landes Bioscience.
Role of chemokines and chemokine receptors in diseases of ageing.
MARIANI, ERMINIA;MARIANI, ADRIANA;FACCHINI, ANDREA
2007
Abstract
Chemokines play an important role in orchestrating leukocyte recruitment and activation during inflammation. Given the ubiquity of chemokines involved in inflammatory tissue destruction, it is not surprising that they contribute to numerous human pathologies. Epidemiological studies have suggested that chronic low-grade inflammation is related to several diseases of ageing with an inflammatory pathogenesis (such as artherosclerosis, type 2 diabetes, osteoarthritis and Alzheimer's disease) and to increased mortality risk. In this chapter, we will briefly review the properties of chemokines ad their receptors and highlight the roles of these chemoattractants in the above selected diseases of ageing.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
