Daily clinical practice and recent molecular studies have clearly shown that primitive liver tumours are an extremely heterogeneous group of disease without a steotyped phenotype or molecular signature. Accumulated evidence strongly supports the notion that such heterogeneity stems from the existence within the liver and along the biliary tree of distinct cells of origin susceptible to diffrent risk of factos and liver injuries. Although this new scenario has yet to be fully elucidated, a new physio-pathological classification of primitive liver tumour subtypes based on different cells of origin has been rpoposed. This new classification not only responds to the urgent need to provide homogeneous diagnostic, prognostic and therapeutic categories for these malignancies, but also seems more coherent with the current epidemiological data and risk factors associated with such diseases. The present chapter summarises current knowledge of the putative different cell types that may serve as cells of origin in primitive liver tumours. It also discusses the proposed new physio-pathological classification of different tumour subtypes based on these cells and it association with the current known risk fqactors for these diseases.
Carcinogenesis of Cholangiocarcinoma
TAVOLARI, SIMONA;BRANDI, GIOVANNI
2015
Abstract
Daily clinical practice and recent molecular studies have clearly shown that primitive liver tumours are an extremely heterogeneous group of disease without a steotyped phenotype or molecular signature. Accumulated evidence strongly supports the notion that such heterogeneity stems from the existence within the liver and along the biliary tree of distinct cells of origin susceptible to diffrent risk of factos and liver injuries. Although this new scenario has yet to be fully elucidated, a new physio-pathological classification of primitive liver tumour subtypes based on different cells of origin has been rpoposed. This new classification not only responds to the urgent need to provide homogeneous diagnostic, prognostic and therapeutic categories for these malignancies, but also seems more coherent with the current epidemiological data and risk factors associated with such diseases. The present chapter summarises current knowledge of the putative different cell types that may serve as cells of origin in primitive liver tumours. It also discusses the proposed new physio-pathological classification of different tumour subtypes based on these cells and it association with the current known risk fqactors for these diseases.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
