We present the current knowledge on the etiology of cholangiocarcinoma. Due to the important differences existing in the epidemiological features of intra- and extrahepatic cholangiocarcinoma, risk factos are discussed separately for ICC and ECC. Well established risk factors include inherited/congenital disorders of the bile ducts (blie duct cysts, primary sclerosing, cholangitis, Caroli's disease), recurrent cholangitis, choledocholithiasis, hepatolithiasis, parasitic infestation, hemochromatosis, Wilson's disease, acquired liver disease (cirrhosis and viral hepatitis)and exposure to Thorotrast. Recent investigations focused on personal and environmental exposures, including cigarette smoking, alcohol consumption, obesity/diabetes and asbestos exposure. Limited knowledge on the role of genetic polymorphisms is available to date.
Farioli, A., Brandi, G. (2015). Risk Factors of Cholangiocarcinoma. New York : Nova Science Publishers, Inc..
Risk Factors of Cholangiocarcinoma
FARIOLI, ANDREA;BRANDI, GIOVANNI
2015
Abstract
We present the current knowledge on the etiology of cholangiocarcinoma. Due to the important differences existing in the epidemiological features of intra- and extrahepatic cholangiocarcinoma, risk factos are discussed separately for ICC and ECC. Well established risk factors include inherited/congenital disorders of the bile ducts (blie duct cysts, primary sclerosing, cholangitis, Caroli's disease), recurrent cholangitis, choledocholithiasis, hepatolithiasis, parasitic infestation, hemochromatosis, Wilson's disease, acquired liver disease (cirrhosis and viral hepatitis)and exposure to Thorotrast. Recent investigations focused on personal and environmental exposures, including cigarette smoking, alcohol consumption, obesity/diabetes and asbestos exposure. Limited knowledge on the role of genetic polymorphisms is available to date.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
