The work deals with the design of a new colon-specific delivery system with improved site specificity and adequate drug release to accommodate different therapeutic needs of peptidic drugs. An anti-infective peptidic drug, Vancomycin, is here entrapped in microcapsules composed by swellable, mucoadhesive and biodegradable albumin nanospheres, coated with fatty acids. These carriers provided suitable drug delivery in the colon environment responding strongly to stimuli such as pH, mucin interactions and enzyme digestion and, for this reason, can be considered good candidates for colon-specific release of drugs presenting very low peroral bioavailability.
B. Luppi, F. Bigucci, A.M. Di Pietra, V. Zecchi (2007). POLYMERIC MICROPARTICLES FOR COLON-SPECIFIC DELIVERY OF VANCOMYCIN. s.l : Grafiche MDM srl.
POLYMERIC MICROPARTICLES FOR COLON-SPECIFIC DELIVERY OF VANCOMYCIN
LUPPI, BARBARA;BIGUCCI, FEDERICA;DI PIETRA, ANNA MARIA;ZECCHI, VITTORIO
2007
Abstract
The work deals with the design of a new colon-specific delivery system with improved site specificity and adequate drug release to accommodate different therapeutic needs of peptidic drugs. An anti-infective peptidic drug, Vancomycin, is here entrapped in microcapsules composed by swellable, mucoadhesive and biodegradable albumin nanospheres, coated with fatty acids. These carriers provided suitable drug delivery in the colon environment responding strongly to stimuli such as pH, mucin interactions and enzyme digestion and, for this reason, can be considered good candidates for colon-specific release of drugs presenting very low peroral bioavailability.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
