Introduction. Studies have shown that exercise only transiently alter the parameters of renal function in healthy subject. However, no studies have longitudinally evaluated the effects of sport on renal function of kidney transplant recipients (KTR). In this study, we analysed longitudinally some indicators of renal function in KTR who regularly practice competitive sport with the aim to evaluate if they showed adverse effects. Methods. Blood and urine test reports of 16 male KTR (mean (SD) age 51 (10) yrs), competing in different sport activities (climbing, cycling, swimming, tennis, track and field, and volleyball) were repeatedly collected across a five-year period. The effect of time (months after transplant) on selected blood chemistry and urine parameters was assessed using linear mixed models with a random intercept on individual subjects. KTR were assuming regular immunosuppressive therapy. Weekly training sessions were recorded. Results. The number of weekly training sessions was superimposable over the five years (2.9 (0.7) sessions/week, 2.2 (1.0) hours/session). The intercepts of haemoglobin (13.16 g/dl) and haematocrit (40.4 %) were slightly lower than the normal reference values, but these parameters did not show a significant effect of time. Urea (intercept: 49.6 mg/dl) was within the range of normality at the time of transplant, and did not significantly change over time. Creatinine (intercept: 1.91 mg/dl) showed values above the normal reference values at the transplant time, but significantly decreased of -0.0037 mg/dl (p<0.05) per month (about 0.044 mg/dL) after transplantation, thus returning towards the range of normal values. Uric acid (intercept: 7.0 mg/dL) and urine specific gravity (intercept: 1012) were within the normal reference values and remained essentially stable over time. Discussion. KTR can resume sports activities showing an overall good renal function in the five years follow up, remaining within the normal reference values. During this period, regular weekly training can be carried out with normal parameters of renal function.
Totti V., Roi G.S., Mosconi G., Di Michele R., Trerotola M., Nanni Costa A. (2015). Longitudinal analysis of renal function in kidney transplanted sportsmen.
Longitudinal analysis of renal function in kidney transplanted sportsmen
TOTTI, VALENTINA;DI MICHELE, ROCCO;
2015
Abstract
Introduction. Studies have shown that exercise only transiently alter the parameters of renal function in healthy subject. However, no studies have longitudinally evaluated the effects of sport on renal function of kidney transplant recipients (KTR). In this study, we analysed longitudinally some indicators of renal function in KTR who regularly practice competitive sport with the aim to evaluate if they showed adverse effects. Methods. Blood and urine test reports of 16 male KTR (mean (SD) age 51 (10) yrs), competing in different sport activities (climbing, cycling, swimming, tennis, track and field, and volleyball) were repeatedly collected across a five-year period. The effect of time (months after transplant) on selected blood chemistry and urine parameters was assessed using linear mixed models with a random intercept on individual subjects. KTR were assuming regular immunosuppressive therapy. Weekly training sessions were recorded. Results. The number of weekly training sessions was superimposable over the five years (2.9 (0.7) sessions/week, 2.2 (1.0) hours/session). The intercepts of haemoglobin (13.16 g/dl) and haematocrit (40.4 %) were slightly lower than the normal reference values, but these parameters did not show a significant effect of time. Urea (intercept: 49.6 mg/dl) was within the range of normality at the time of transplant, and did not significantly change over time. Creatinine (intercept: 1.91 mg/dl) showed values above the normal reference values at the transplant time, but significantly decreased of -0.0037 mg/dl (p<0.05) per month (about 0.044 mg/dL) after transplantation, thus returning towards the range of normal values. Uric acid (intercept: 7.0 mg/dL) and urine specific gravity (intercept: 1012) were within the normal reference values and remained essentially stable over time. Discussion. KTR can resume sports activities showing an overall good renal function in the five years follow up, remaining within the normal reference values. During this period, regular weekly training can be carried out with normal parameters of renal function.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
