New Perspectives and Processes in Enantioselective catalytic Aldol Reactions

The aldol reaction is a powerful and important synthetic transformation widely employed in the total synthesis of complex organic molecules It is used to access polyketide with their peculiar 1,3 oxygenation fragment and also to prepare a variety of other compounds such as a and b-aminoacids, nucleosides and heterocyclic compounds. In the past 20 years two complementary general approaches have been used for the asymmetric aldol reactions. In the diastereoselective methodologies, a chiral controlling element, bound in a covalent manner to the generated enolate, it was able to control the stereochemical course of the reaction.