Recent advances in hematopoietic cell ­transplantation and a broadening array of salvage chemotherapy options have extended the survival of patients with hematological cancers, but can result in prolonged periods of immunosuppression and susceptibility to invasive ­fungal infections. Among these high-risk patient populations, systemic antifungal therapy is administered episodically or sometimes continuously for months or even years, increasing concerns for the development of antifungal resistance. As newer triazoles (voriconazole and posaconazole) and echinocandins (anidulafungin, caspofungin, and micafungin) have supplanted amphotericin B formulations as the preferred antifungal therapies for primary and secondary prophylaxis, pharmacokinetic variability inherent to the triazoles as well as emerging patterns of intrinsic and acquired antifungal resistance are becoming increasingly important factors in the long-term management of invasive fungal infections. In this chapter, we review recent data concerning antifungal drug resistance for these newer azoles and echinocandins, as well as key considerations in drug dosing.

Lewis, Perlin David S. (2011). Fungal Drug Resistance and Pharmacologic Considerations of Dosing Newer Antifungal Therapies. New York : Safdar, Amar [10.1007/978-1-60761-644-3_28].

Fungal Drug Resistance and Pharmacologic Considerations of Dosing Newer Antifungal Therapies

LEWIS, RUSSEL EDWARD;
2011

Abstract

Recent advances in hematopoietic cell ­transplantation and a broadening array of salvage chemotherapy options have extended the survival of patients with hematological cancers, but can result in prolonged periods of immunosuppression and susceptibility to invasive ­fungal infections. Among these high-risk patient populations, systemic antifungal therapy is administered episodically or sometimes continuously for months or even years, increasing concerns for the development of antifungal resistance. As newer triazoles (voriconazole and posaconazole) and echinocandins (anidulafungin, caspofungin, and micafungin) have supplanted amphotericin B formulations as the preferred antifungal therapies for primary and secondary prophylaxis, pharmacokinetic variability inherent to the triazoles as well as emerging patterns of intrinsic and acquired antifungal resistance are becoming increasingly important factors in the long-term management of invasive fungal infections. In this chapter, we review recent data concerning antifungal drug resistance for these newer azoles and echinocandins, as well as key considerations in drug dosing.
2011
Principles and Practice of Cancer Infectious Diseases
317
329
Lewis, Perlin David S. (2011). Fungal Drug Resistance and Pharmacologic Considerations of Dosing Newer Antifungal Therapies. New York : Safdar, Amar [10.1007/978-1-60761-644-3_28].
Lewis; Perlin David S.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/414170
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