Advances in the supportive care and treatment of hematologic malignancies have markedly improved the life expectancy of afflicted patients, but this progress is increasingly at the expense of developing a wider range of infectious complications often caused by drug-resistant organisms. The clinical approach to infections occurring among hematology patients involves understanding host immune system defects and anatomic barrier disruption that predispose patients to infection (Figure 91-1). This chapter reviews specific hematologic conditions for their unique host defence defects and associated infections (Table 91–1), and the differential diagnoses of common infectious pathogens (Table 91–2). To demonstrate how periods of predictable anatomic defects combine with severe immune compromise, the prevention, diagnosis, and management strategies for infections occurring in the hematopoietic stem cell transplantation (HCT) recipient are presented as models.
Chapter 91. Clinical approach to infections in the immunocompromised host
LEWIS, RUSSEL EDWARD;
2013
Abstract
Advances in the supportive care and treatment of hematologic malignancies have markedly improved the life expectancy of afflicted patients, but this progress is increasingly at the expense of developing a wider range of infectious complications often caused by drug-resistant organisms. The clinical approach to infections occurring among hematology patients involves understanding host immune system defects and anatomic barrier disruption that predispose patients to infection (Figure 91-1). This chapter reviews specific hematologic conditions for their unique host defence defects and associated infections (Table 91–1), and the differential diagnoses of common infectious pathogens (Table 91–2). To demonstrate how periods of predictable anatomic defects combine with severe immune compromise, the prevention, diagnosis, and management strategies for infections occurring in the hematopoietic stem cell transplantation (HCT) recipient are presented as models.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
