Although some studies suggest an association between the exposition to urban pollutants and lung cancer in dogs, the relationship between the deposition of black dust matter in lung (also termed anthracosis) and primary pulmonary carcinoma has never been investigated. In order to clarify this association we have scored the deposit of particulate matter (PM) in lung tissue of dogs with primary carcinoma and evaluated the correlation with the tumour histological type and grade. 34 canine lung tumours out of 64 selected from our records (formalin fixed, paraffin embedded, HE stain) were diagnosed as primary carcinoma on the basis of necropsy report, histological pattern and TTF-1 immunohistochemistry, and classified (WHO 1999) as 16 papillary adenocarcinoma, 1 acinar adenocarcinoma, 9 bronchioloalveolar carcinoma, 1 squamous carcinoma, 2 adenosquamous carcinoma, 4 large cell carcinoma, 1 bronchial gland carcinoma; the histological grading (McNiel et al, JAVMA 1997) prompted grade I in 7 cases, grade II in 20 cases and grade III in 7 cases. Non-tumourous lung tissue in all cases of primary carcinomas displayed a considerable amount of black dusts within macrophages in the peribronchiolar and perivascular interstitium; PM score (Schoning et al, AJVR 1996) was 1 (minimal amount) in 4 cases, 2 (moderate) in 12 cases and 3 (massive) in 18 cases; in 13 cases there was also huge evidence of PM within tumour tissue. Nevertheless, there was no significant relationship (ANOVA) among PM score and the histological type or grade. The comparison of PM score in lungs with primary carcinoma with PM score in another series of 164 randomly selected canine lungs (Bettini et al, ProcESVP 2005) evidenced in the former group a significantly higher (p=0,0009) deposit of inhaled dusts. These findings strongly suggest that canine pulmonary carcinomas more frequently develop in heavily anthracotic lungs, which may reflects the effect of inhaled carcinogens from urban pollutants.
Bettini G., Morini M., Marcato P.S. (2006). Putative role of inhaled dusts in the development of canine lung carcinoma. s.l : ESVP 2006 Organising Committee.
Putative role of inhaled dusts in the development of canine lung carcinoma
BETTINI, GIULIANO;MORINI, MARIA;MARCATO, PAOLO STEFANO
2006
Abstract
Although some studies suggest an association between the exposition to urban pollutants and lung cancer in dogs, the relationship between the deposition of black dust matter in lung (also termed anthracosis) and primary pulmonary carcinoma has never been investigated. In order to clarify this association we have scored the deposit of particulate matter (PM) in lung tissue of dogs with primary carcinoma and evaluated the correlation with the tumour histological type and grade. 34 canine lung tumours out of 64 selected from our records (formalin fixed, paraffin embedded, HE stain) were diagnosed as primary carcinoma on the basis of necropsy report, histological pattern and TTF-1 immunohistochemistry, and classified (WHO 1999) as 16 papillary adenocarcinoma, 1 acinar adenocarcinoma, 9 bronchioloalveolar carcinoma, 1 squamous carcinoma, 2 adenosquamous carcinoma, 4 large cell carcinoma, 1 bronchial gland carcinoma; the histological grading (McNiel et al, JAVMA 1997) prompted grade I in 7 cases, grade II in 20 cases and grade III in 7 cases. Non-tumourous lung tissue in all cases of primary carcinomas displayed a considerable amount of black dusts within macrophages in the peribronchiolar and perivascular interstitium; PM score (Schoning et al, AJVR 1996) was 1 (minimal amount) in 4 cases, 2 (moderate) in 12 cases and 3 (massive) in 18 cases; in 13 cases there was also huge evidence of PM within tumour tissue. Nevertheless, there was no significant relationship (ANOVA) among PM score and the histological type or grade. The comparison of PM score in lungs with primary carcinoma with PM score in another series of 164 randomly selected canine lungs (Bettini et al, ProcESVP 2005) evidenced in the former group a significantly higher (p=0,0009) deposit of inhaled dusts. These findings strongly suggest that canine pulmonary carcinomas more frequently develop in heavily anthracotic lungs, which may reflects the effect of inhaled carcinogens from urban pollutants.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
