Introduction. Recent studies on adults and children with migraine have revealed either cortical hyperexcitability or loss of habituation using different Erp paradigms. The aim of the present study was to investigate both phenomena by measuring different cortical responses (recorded in different experimental conditions) within the same patients. Method. Subjects were 10 children (ages 9–15 years) diagnosed as suffering from migraine without aura following the IHS criteria and 10 age-matched controls. P300 amplitudes and latencies were recorded from Fz, Cz, and Pz during a passive and an active version of acoustic oddball paradigm, while CNV and its subcomponents (iCnv, lCNV) were recorded in the same sites during the interval of 3 s between S1 and S2 in a CNV classic paradigm. Results. The migraine group displayed a significantly prolonged latency of P300, particularly during the active version of the oddball task (F(1,19) = 7.1, P = 0.02). Migrainous subjects did not differ from healthy controls in the amplitudes of P300, tCNV, iCNV and lCNV. Analyses of habituation evidenced that migrainous children showed a lower habituation than healthy controls of P300 amplitudes (F(2,38) = 5.03, P = 0.01). Discussion. Present results suggest that children suffering from migraine without aura have an increased cognitive processing time and a lower habituation of cortical responses.
Russo P.M., Violani C., Cionfrini L., Lisanti L., Rocchetti G., Galli F., et al. (2004). Event-related potentials in migraine: investigating information processing and habituation.
Event-related potentials in migraine: investigating information processing and habituation
Russo P. M.;
2004
Abstract
Introduction. Recent studies on adults and children with migraine have revealed either cortical hyperexcitability or loss of habituation using different Erp paradigms. The aim of the present study was to investigate both phenomena by measuring different cortical responses (recorded in different experimental conditions) within the same patients. Method. Subjects were 10 children (ages 9–15 years) diagnosed as suffering from migraine without aura following the IHS criteria and 10 age-matched controls. P300 amplitudes and latencies were recorded from Fz, Cz, and Pz during a passive and an active version of acoustic oddball paradigm, while CNV and its subcomponents (iCnv, lCNV) were recorded in the same sites during the interval of 3 s between S1 and S2 in a CNV classic paradigm. Results. The migraine group displayed a significantly prolonged latency of P300, particularly during the active version of the oddball task (F(1,19) = 7.1, P = 0.02). Migrainous subjects did not differ from healthy controls in the amplitudes of P300, tCNV, iCNV and lCNV. Analyses of habituation evidenced that migrainous children showed a lower habituation than healthy controls of P300 amplitudes (F(2,38) = 5.03, P = 0.01). Discussion. Present results suggest that children suffering from migraine without aura have an increased cognitive processing time and a lower habituation of cortical responses.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
