DOPET arises from a collaboration among different groups within INFN (Istituto Nazionale di Fisica Nucleare): Pisa and Bologna researchers will cooperate with the CATANA group at LNS (Catania). DOPET aims to perform a feasibility study for verifying the applicability of an in-beam-PET for indirect extrapolation of radiation range in tissues, in the field of proton therapy. With the DoPET project we want to perform an evaluation of detection efficiency and spatial resolution that can be achieved with a dedicated PET system, in order to propel further developments in the field of relative dosimetry. The project provides the realization of a prototype for a compact two-head PET, allowing the maximum angular cover within the volume available in the therapy room. The prototype will be used for the comparison of activity profiles obtained by measurements on phantoms and GEANT4-based simulations. Due to the limited angular acceptance of the prototype, the exact reconstruction of the image in all the three dimension cannot be achieved. However, to the purpose of verifying the utility of an in-beam PET, the most important result is to reach resolution of the order of the millimeter for the proton range. The depth profile is in fact the most critical issue of proton therapy, while the lateral beam spread is similar for carbon ions and protons. Each PET head will be made of a position-sensitive photomultiplier Hamamatsu H8500 coupled with a matrix of high light yield crystal pixels. The dimensions of the matrix will match those of the active area of the PMT, i.e. 49x49 mm2, each pixel being 2x2 mm2 large and 1.5 interaction lengths deep. In order to achieve a satisfying energetic and spatial resolution, crystal choice will be oriented towards LYSO. The collaboration with institutes provided of medical proton beams, such as CATANA (LNS, Italy), will allow us to carry out measurements on phantoms by using the prototype built. The PET prototype, for irradiations of the order of 15 Gy, will provides counting rates lower than 20 Hz. By acquiring positron annihilation events for ten minutes, the resulting statistic will be about 104 events, about one hundred times lower than that of standard PET images.
V. Rosso, N. Lanconelli (2006). Dosimetry PET (DOPET).
Dosimetry PET (DOPET)
LANCONELLI, NICO
2006
Abstract
DOPET arises from a collaboration among different groups within INFN (Istituto Nazionale di Fisica Nucleare): Pisa and Bologna researchers will cooperate with the CATANA group at LNS (Catania). DOPET aims to perform a feasibility study for verifying the applicability of an in-beam-PET for indirect extrapolation of radiation range in tissues, in the field of proton therapy. With the DoPET project we want to perform an evaluation of detection efficiency and spatial resolution that can be achieved with a dedicated PET system, in order to propel further developments in the field of relative dosimetry. The project provides the realization of a prototype for a compact two-head PET, allowing the maximum angular cover within the volume available in the therapy room. The prototype will be used for the comparison of activity profiles obtained by measurements on phantoms and GEANT4-based simulations. Due to the limited angular acceptance of the prototype, the exact reconstruction of the image in all the three dimension cannot be achieved. However, to the purpose of verifying the utility of an in-beam PET, the most important result is to reach resolution of the order of the millimeter for the proton range. The depth profile is in fact the most critical issue of proton therapy, while the lateral beam spread is similar for carbon ions and protons. Each PET head will be made of a position-sensitive photomultiplier Hamamatsu H8500 coupled with a matrix of high light yield crystal pixels. The dimensions of the matrix will match those of the active area of the PMT, i.e. 49x49 mm2, each pixel being 2x2 mm2 large and 1.5 interaction lengths deep. In order to achieve a satisfying energetic and spatial resolution, crystal choice will be oriented towards LYSO. The collaboration with institutes provided of medical proton beams, such as CATANA (LNS, Italy), will allow us to carry out measurements on phantoms by using the prototype built. The PET prototype, for irradiations of the order of 15 Gy, will provides counting rates lower than 20 Hz. By acquiring positron annihilation events for ten minutes, the resulting statistic will be about 104 events, about one hundred times lower than that of standard PET images.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
