This formulation concerns a new pharmaceutical combination which can be used for the treatment of muscular pain and acute lombalgia. It consists of a topical vehicle containing a combination of a non steroid anti-inflammatory drug (NSAID) and a commonly used therapeutical substance that can act synergically in order to achieve a relatively high level of efficacy . The particular formulation provides the topical system with properties such as: *Improved application properties with respect to the traditional formulations like creams and ointments; *More rapid and complete transfer of the active ingredient from the vehicle to the skin and consequent greater efficacy; *The product is easy to spread, favouring application on large areas of skin; *The product is not greasy and does not leave traces after application; *Excellent skin-feel; *Easier penetration of the drugs through the skin due to the presence of absorption promoters; *In vitro and in vivo tests have demonstrated that the active ingredients are quickly absorbed; *In vivo tests, on healthy consenting volunteers, have confirmed the surprising anti-inflammatory and analgesic activity of the emulgels produced according to this invention. The onset of beneficial effects is rapid and effective almost to the same extent as an injectable administration. The various emulgels according to this invention are of interest from a formulation and functional point of view as they improve the parameters of permeation and increase the characteristics of absorption of the active ingredients in question with respect to commercial formulations that contain the same drugs.

Anti-inflammatory formulation for topical use.

RODRIGUEZ, LORENZO;DI PIETRA, ANNA MARIA;CAVALLARI, CRISTINA;LUPPI, BARBARA;
2006

Abstract

This formulation concerns a new pharmaceutical combination which can be used for the treatment of muscular pain and acute lombalgia. It consists of a topical vehicle containing a combination of a non steroid anti-inflammatory drug (NSAID) and a commonly used therapeutical substance that can act synergically in order to achieve a relatively high level of efficacy . The particular formulation provides the topical system with properties such as: *Improved application properties with respect to the traditional formulations like creams and ointments; *More rapid and complete transfer of the active ingredient from the vehicle to the skin and consequent greater efficacy; *The product is easy to spread, favouring application on large areas of skin; *The product is not greasy and does not leave traces after application; *Excellent skin-feel; *Easier penetration of the drugs through the skin due to the presence of absorption promoters; *In vitro and in vivo tests have demonstrated that the active ingredients are quickly absorbed; *In vivo tests, on healthy consenting volunteers, have confirmed the surprising anti-inflammatory and analgesic activity of the emulgels produced according to this invention. The onset of beneficial effects is rapid and effective almost to the same extent as an injectable administration. The various emulgels according to this invention are of interest from a formulation and functional point of view as they improve the parameters of permeation and increase the characteristics of absorption of the active ingredients in question with respect to commercial formulations that contain the same drugs.
RESEARCH TO BUSINESS - RESEARCH RENEWS BUSINESS
38
39
L Rodriguez; A. M. Di Pietra; C. Cavallari; B. Luppi; C. Roberti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/36180
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