Purpose: To investigate the effect of Lemon Myrtle Oil as a preservative in a moisturizing cream or shampoo. Lemon Myrtle Oil was evaluated as pure oil or in a liposomal system. Methods: Large unilamellar vesicles were prepared by a solvent injection method. Liposomes size and stability were evaluated by Dynamic Light Scattering (DLS), while the loading efficiency was determined by gas-chromatographic analysis. Minimum Inhibitory Concentration (MIC) of pure Lemon Myrtle Oil and essential oil in the carrier were obtained. Subsequently the pure oil and the liposomal system were introduced in a standard biphasic formulation (O/W cream) or in a monophasic formulation (shampoo) and their preservative properties were evaluated by challege tests. Stability tests were performed on the formulations containing the pure preservative or the liposomal system. Results: MIC data suggested that the antimicrobial activity of pure Lemon Myrtle Oil was lower than that of the oil in a liposomal system. Challenge tests showed that the preservative efficacy of encapsulated oil increased with respect to pure essential oil only in the monophasic formulation. Conclusions: For pure or encapsulated Lemon Myrtle Oil, stability tests and antimicrobial data indicated its potential application as a natural preservative in personal care products and cosmetics.
L. Monaco, B. Luppi, Beatrice Vitali, Francesca Lasagna, F. Bigucci, V. Zecchi (2006). Liposomes carrying lemon myrtle oil as a natural preservative system. s.l : s.n.
Liposomes carrying lemon myrtle oil as a natural preservative system
LUPPI, BARBARA;VITALI, BEATRICE;BIGUCCI, FEDERICA;ZECCHI, VITTORIO
2006
Abstract
Purpose: To investigate the effect of Lemon Myrtle Oil as a preservative in a moisturizing cream or shampoo. Lemon Myrtle Oil was evaluated as pure oil or in a liposomal system. Methods: Large unilamellar vesicles were prepared by a solvent injection method. Liposomes size and stability were evaluated by Dynamic Light Scattering (DLS), while the loading efficiency was determined by gas-chromatographic analysis. Minimum Inhibitory Concentration (MIC) of pure Lemon Myrtle Oil and essential oil in the carrier were obtained. Subsequently the pure oil and the liposomal system were introduced in a standard biphasic formulation (O/W cream) or in a monophasic formulation (shampoo) and their preservative properties were evaluated by challege tests. Stability tests were performed on the formulations containing the pure preservative or the liposomal system. Results: MIC data suggested that the antimicrobial activity of pure Lemon Myrtle Oil was lower than that of the oil in a liposomal system. Challenge tests showed that the preservative efficacy of encapsulated oil increased with respect to pure essential oil only in the monophasic formulation. Conclusions: For pure or encapsulated Lemon Myrtle Oil, stability tests and antimicrobial data indicated its potential application as a natural preservative in personal care products and cosmetics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
