Aim. The recent increase in the use of cellular phones has raised public concern about health risk associated with brain exposure to radio frequency electromagnetic fields (RF-EMFs). Aim of the present study was to verify if acute exposure to either continuous wave (CW) or GSM-modulated 900 MHz RF-EMF could affect the permeability of voltage-gated calcium channels (VGCC) in neurons. Methods. Primary cultures of rat cortical neurons were exposed for periods of 90 s to either CW (2 or 4 W/kg) or GSM-modulated (2 W/kg) 900 MHz RF-EMF during whole-cell patch-clamp recording of Ba2+ currents (IBa2+) through VGCC. Results. Single or multiple (two-three) acute (90 s) exposure to either CW or GSM-modulated 900 MHz RF-EMF did not significantly alter the current amplitude or the current-voltage relationship of IBa2+ through VGCC. Conclusions. The permeability of VGCC in the tested neurons was not affected by acute exposure to either CW or GSM-modulated 900 MHz RF-EMF. Possible interactions with other mechanisms involved in the control of [Ca2+]i can not be ruled out by the present study.

Acute exposure to CW or GSM-modulated 900 MHz radiofrequency does not affect Ba2+ currents through voltage-gated calcium channels in rat cortical neurons

PLATANO, DANIELA;MESIRCA, PIETRO;BERSANI, FERDINANDO;AICARDI, GIORGIO
2006

Abstract

Aim. The recent increase in the use of cellular phones has raised public concern about health risk associated with brain exposure to radio frequency electromagnetic fields (RF-EMFs). Aim of the present study was to verify if acute exposure to either continuous wave (CW) or GSM-modulated 900 MHz RF-EMF could affect the permeability of voltage-gated calcium channels (VGCC) in neurons. Methods. Primary cultures of rat cortical neurons were exposed for periods of 90 s to either CW (2 or 4 W/kg) or GSM-modulated (2 W/kg) 900 MHz RF-EMF during whole-cell patch-clamp recording of Ba2+ currents (IBa2+) through VGCC. Results. Single or multiple (two-three) acute (90 s) exposure to either CW or GSM-modulated 900 MHz RF-EMF did not significantly alter the current amplitude or the current-voltage relationship of IBa2+ through VGCC. Conclusions. The permeability of VGCC in the tested neurons was not affected by acute exposure to either CW or GSM-modulated 900 MHz RF-EMF. Possible interactions with other mechanisms involved in the control of [Ca2+]i can not be ruled out by the present study.
18 (P4)
18 (P4)
ACTA PHYSIOLOGICA
Platano D.; Mesirca P.; Paffi A.; Pellegrino M.; Liberti M.; Apollonio F.; Bersani F.; Aicardi G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/33596
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