Cystatin B was first described as an inhibitor of the cysteine family of proteases. Its biochemical properties have been studied in depth, the crystal structure of the protein has been determined and its enzymatic activity characterized. However, evidence from the literature suggests that cystatin B has alternative functions in addition to the inhibition of proteases. In this review we will discuss the results obtained from a number of laboratories, which detail such novel biological roles for cystatin B. In particular, we will discuss some of the pathologies involving the absence or presence of the protein. We will briefly summarize the function and structure of the protein, its possible involvement in tumoural growth and apoptosis, neurodegenerative diseases and immune response. The expression and cellular localization of cystatin B will be analyzed in different cell types and in developing rat cerebellum. The pattern will be matched to the expression of newly identified proteins that specifically interact with cystatin B. On the basis of all the experimental evidence we aim to propose a cytoplasmic function for cystatin B not necessarily related to its anti-protease activity.

Di Giaimo R., Cipollini E, Riccio M, Santi S, Hoque M, Dembic M, et al. (2006). Alternative Functions for Cystatin B implicated by its interaction with Proteins other than Prote. NEW YORK : NOVA Publishers, Inc.

Alternative Functions for Cystatin B implicated by its interaction with Proteins other than Prote

CIPOLLINI, ELENA;HOQUE, MARTHA;CARONE, SIMONA;MELLI, MARIALUISA
2006

Abstract

Cystatin B was first described as an inhibitor of the cysteine family of proteases. Its biochemical properties have been studied in depth, the crystal structure of the protein has been determined and its enzymatic activity characterized. However, evidence from the literature suggests that cystatin B has alternative functions in addition to the inhibition of proteases. In this review we will discuss the results obtained from a number of laboratories, which detail such novel biological roles for cystatin B. In particular, we will discuss some of the pathologies involving the absence or presence of the protein. We will briefly summarize the function and structure of the protein, its possible involvement in tumoural growth and apoptosis, neurodegenerative diseases and immune response. The expression and cellular localization of cystatin B will be analyzed in different cell types and in developing rat cerebellum. The pattern will be matched to the expression of newly identified proteins that specifically interact with cystatin B. On the basis of all the experimental evidence we aim to propose a cytoplasmic function for cystatin B not necessarily related to its anti-protease activity.
2006
Human Stefins and Cystatins, Nova Science Publishers
43
59
Di Giaimo R., Cipollini E, Riccio M, Santi S, Hoque M, Dembic M, et al. (2006). Alternative Functions for Cystatin B implicated by its interaction with Proteins other than Prote. NEW YORK : NOVA Publishers, Inc.
Di Giaimo R.; Cipollini E; Riccio M; Santi S; Hoque M; Dembic M; Palmieri P; Carone S; Melli M.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/32679
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact