Background Few studies have evaluated the changes in renal function of transplant recipients (TR) after intense physical activity. Methods The purpose of this study was to investigate some aspects of renal function in TR participating in a road cycling race (CR) of 130km long (total climb: 1871m, uphill 50km, downhill 46km and 34km flat). Venous blood and urine samples were collected: i) the day before (Pre), ii) at the finish (Post), iii) 24 hours (24h) after CR from 20TR (mean±SD age 52±10yrs, 72±11kg, 173±0cm, 24.1±2.9kg/m2), who underwent transplant (2 heart, 5 liver, 11 kidney, 2 bone marrow) 8.8±4.9yrs before. Forty-four healthy subjects (HS) (52±9yrs, 73±9kg, 175±0cm, 23.8±2.2kg/m2) participating to the same race were recruited as control group. From the group of TR, we also collected data from 6 TR who have participated in two editions (2012-2013) of the same race. Results All the participants completed CR without problems. No significant differences were found in the mean race time in both groups (6.36.49±1.15.14 vs 6.03.27±0.47.24 hh.mm.ss). Significant differences were found between Pre-Post and Post-24h in TR and HS in urea (Pre 45±14, Post 68±20, 24h 62±16 vs Pre 38±8, Post 55±11, 24h 51±7 mg/dL; P<0.05), creatinine (Pre 1.12±0.36, Post 1.37±0.42, 24h 1.16±0.38 vs Pre 0.92±0.16, Post 1.09±0.22, 24h 0.94±0.15 mg/dL; P<0.05), urinary proteins (Pre 148±99, Post 341±345, 24h 126±133 vs Pre 73±40, Post 116±79, 24h 104±35 mg/die P<0.05) and microalbuminuria (Pre 54±75, Post 192±278, 24h 35±59 vs Pre 11±18, Post 36±44, 24h 8±4 mg/L; P<0.05). In both groups values significantly increased between Pre-Post and decreased between Post-24h. In the urine specific gravity values significant differences were found between Pre-24h in both groups (Pre 1.015±0.004, Post 1.017±0.005, 24h 1.016±0.006 vs Pre 1.018±0.005, Post 1.020±0.005, 24h 1.027±0.005; P<0.05) and between groups in 24h (P<0.05). Longitudinally there was no significant difference in Pre, Post and 24h in the two editions of the race. Conclusions TR in good clinical conditions and properly trained, were able to face intense physical effort with transient changes in renal function. The variations observed are superimposable in TR and in HS and have a similar trend. The lower urine specific gravity in TR is related to a tubular dysfunction partially due to immunosuppresive therapy. The increase of proteinuria resolves after rest. More longitudinal studies are necessary to understand the eventual risk of endurance sports activities (CR) for renal function of TR.
TOTTI V., ZANCANARO M., DI MICHELE R., MOSCONI G., BELTRANDI E., NANNI COSTA A., et al. (2014). RENAL FUNCTION IN TRANSPLANT RECIPIENTS COMPARE TO HEALTHY SUBJECTS AFTER A MARATHON CYCLING.
RENAL FUNCTION IN TRANSPLANT RECIPIENTS COMPARE TO HEALTHY SUBJECTS AFTER A MARATHON CYCLING
TOTTI, VALENTINA;DI MICHELE, ROCCO;
2014
Abstract
Background Few studies have evaluated the changes in renal function of transplant recipients (TR) after intense physical activity. Methods The purpose of this study was to investigate some aspects of renal function in TR participating in a road cycling race (CR) of 130km long (total climb: 1871m, uphill 50km, downhill 46km and 34km flat). Venous blood and urine samples were collected: i) the day before (Pre), ii) at the finish (Post), iii) 24 hours (24h) after CR from 20TR (mean±SD age 52±10yrs, 72±11kg, 173±0cm, 24.1±2.9kg/m2), who underwent transplant (2 heart, 5 liver, 11 kidney, 2 bone marrow) 8.8±4.9yrs before. Forty-four healthy subjects (HS) (52±9yrs, 73±9kg, 175±0cm, 23.8±2.2kg/m2) participating to the same race were recruited as control group. From the group of TR, we also collected data from 6 TR who have participated in two editions (2012-2013) of the same race. Results All the participants completed CR without problems. No significant differences were found in the mean race time in both groups (6.36.49±1.15.14 vs 6.03.27±0.47.24 hh.mm.ss). Significant differences were found between Pre-Post and Post-24h in TR and HS in urea (Pre 45±14, Post 68±20, 24h 62±16 vs Pre 38±8, Post 55±11, 24h 51±7 mg/dL; P<0.05), creatinine (Pre 1.12±0.36, Post 1.37±0.42, 24h 1.16±0.38 vs Pre 0.92±0.16, Post 1.09±0.22, 24h 0.94±0.15 mg/dL; P<0.05), urinary proteins (Pre 148±99, Post 341±345, 24h 126±133 vs Pre 73±40, Post 116±79, 24h 104±35 mg/die P<0.05) and microalbuminuria (Pre 54±75, Post 192±278, 24h 35±59 vs Pre 11±18, Post 36±44, 24h 8±4 mg/L; P<0.05). In both groups values significantly increased between Pre-Post and decreased between Post-24h. In the urine specific gravity values significant differences were found between Pre-24h in both groups (Pre 1.015±0.004, Post 1.017±0.005, 24h 1.016±0.006 vs Pre 1.018±0.005, Post 1.020±0.005, 24h 1.027±0.005; P<0.05) and between groups in 24h (P<0.05). Longitudinally there was no significant difference in Pre, Post and 24h in the two editions of the race. Conclusions TR in good clinical conditions and properly trained, were able to face intense physical effort with transient changes in renal function. The variations observed are superimposable in TR and in HS and have a similar trend. The lower urine specific gravity in TR is related to a tubular dysfunction partially due to immunosuppresive therapy. The increase of proteinuria resolves after rest. More longitudinal studies are necessary to understand the eventual risk of endurance sports activities (CR) for renal function of TR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
