The mechanisms and the pathways whereby exercise training increases heart vascularization will be reviewed; neo-angiogenesis involves the formation of new capillaries, which typically occurs with the mechanism of intussusception. In addition, physical exercise favors neo-vasculogenesis, by inducing the mobilization of bone marrow-derived endothelial progenitor cells (EPCs) which contribute to the repair and regeneration of injured endothelia. New data will be presented suggesting that also bone marrow-derived mesenchymal adult stem cells (MASCs) may be recruited to the cardiac tissue by exercise training. The therapeutic potential of these cell populations will be addressed.
EXERCISE TRAINING-MEDIATED ANGIOGENESIS AND RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR AND STEM CELLS TO THE CARDIAC TISSUE
MARINI, MARINA;MARCHIONNI, COSETTA;ABRUZZO, PROVVIDENZA MARIA
2014
Abstract
The mechanisms and the pathways whereby exercise training increases heart vascularization will be reviewed; neo-angiogenesis involves the formation of new capillaries, which typically occurs with the mechanism of intussusception. In addition, physical exercise favors neo-vasculogenesis, by inducing the mobilization of bone marrow-derived endothelial progenitor cells (EPCs) which contribute to the repair and regeneration of injured endothelia. New data will be presented suggesting that also bone marrow-derived mesenchymal adult stem cells (MASCs) may be recruited to the cardiac tissue by exercise training. The therapeutic potential of these cell populations will be addressed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
