In the present work microparticles prepared by Hot air Coating (HAC) technique and costing of nifedipine (nife), cetearyl alcohol (CA) and Pluronic F68 (F68) were investigated as a potential therapeutic system. The characteristics of these microparticles were evaluated by thermogravimetric analysis electron microscopy and dissolution study. The results obtained by TGA, SEM and dissolution study show that Hot Air Coating technique significantly modifies the morphology of the nife-CA/F68 system and the dissolution of nifedipine. Moreover, it can be drawn that Pluronic F68 allows to modulate the release of nifedipine coated with cetearyl alcohol by this new spray process.
L. Giovannelli, F. Pattarino, S. Bellomi, B. Albertini (2005). Study of the effect of Pluronic F68 on nifedipine microparticles prepared by Hot Air Coating Technique.. PARMA : TEFARCO.
Study of the effect of Pluronic F68 on nifedipine microparticles prepared by Hot Air Coating Technique.
ALBERTINI, BEATRICE
2005
Abstract
In the present work microparticles prepared by Hot air Coating (HAC) technique and costing of nifedipine (nife), cetearyl alcohol (CA) and Pluronic F68 (F68) were investigated as a potential therapeutic system. The characteristics of these microparticles were evaluated by thermogravimetric analysis electron microscopy and dissolution study. The results obtained by TGA, SEM and dissolution study show that Hot Air Coating technique significantly modifies the morphology of the nife-CA/F68 system and the dissolution of nifedipine. Moreover, it can be drawn that Pluronic F68 allows to modulate the release of nifedipine coated with cetearyl alcohol by this new spray process.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
