Objectives. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is increasingly used in diagnosis of pancreatic tumors. Our study aims to identify cytological characteristics of on-site evaluation helpful for recognizing pancreatic neuroendocrine tumors (NETs). Methods. Our study comprises 5 cases of pancreatic tumors with cytological features suggestive of neuroendocrine origin, obtained by EUS-FNA which diagnosis was confirmed by surgical excision. For each case we analized: cytological smears, cell block sections and immunocytochemical stains. Results. All cases show similar and peculiar cytological characteristics of on-site evaluation: smears were richly cellular with poorly cohesive small cells; they display a monotonous basophilic appearance with scanty cytoplasm and small eccentric nucleus with speckled or dusty chromatin pattern conferring a plasmocytoid appearance. Immunocytochemical stains (Chromogranin A, Synaptophysin), performed on cell-block, confirmed neuroendocrine differentiation. Conclusion. EUS-FNA is a useful method of identification of pancreatic NETs. Recognizing cytopathological features of neuroendocrine origin improves the diagnostic yield of the procedure, allowing a three-tiered approach in planning the handling of FNA specimens.
On-site cytopathological evaluation of endoscopic ultrasound-guided fine needle aspiration of pancreatic neuroendocrine tumors / P. Campisi; G. Accinelli; C. De Angelis*; I. Castellano; S. Asioli; D. Pacchioni; G. Bussolati. - In: PATHOLOGICA. - ISSN 1591-951X. - STAMPA. - 99 (5):(2007), pp. 317--. (Intervento presentato al convegno Adriatic Society of Pathology - 22nd International Meeting tenutosi a GROTTAMMARE (AP) nel 22-24 GIUGNO 2007).
On-site cytopathological evaluation of endoscopic ultrasound-guided fine needle aspiration of pancreatic neuroendocrine tumors
ASIOLI, SOFIA;
2007
Abstract
Objectives. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is increasingly used in diagnosis of pancreatic tumors. Our study aims to identify cytological characteristics of on-site evaluation helpful for recognizing pancreatic neuroendocrine tumors (NETs). Methods. Our study comprises 5 cases of pancreatic tumors with cytological features suggestive of neuroendocrine origin, obtained by EUS-FNA which diagnosis was confirmed by surgical excision. For each case we analized: cytological smears, cell block sections and immunocytochemical stains. Results. All cases show similar and peculiar cytological characteristics of on-site evaluation: smears were richly cellular with poorly cohesive small cells; they display a monotonous basophilic appearance with scanty cytoplasm and small eccentric nucleus with speckled or dusty chromatin pattern conferring a plasmocytoid appearance. Immunocytochemical stains (Chromogranin A, Synaptophysin), performed on cell-block, confirmed neuroendocrine differentiation. Conclusion. EUS-FNA is a useful method of identification of pancreatic NETs. Recognizing cytopathological features of neuroendocrine origin improves the diagnostic yield of the procedure, allowing a three-tiered approach in planning the handling of FNA specimens.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
