CRIS Current Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishDiclofenac, a non steroidal anti-inflammatory drug, is poorly soluble in water and exists as dimers in the solid state, bound together hydrogen bondings, involving the carboxylic groups, which are destroyed by the formation of a salt. Salts of alkaline metals are hydrate: their solubility in water is not so high as that of other sodium or potassium NSAID salts, and their behavior in water solution suggests self-aggregation. Salts formed with hydroxy aliphatic amines, despite the hydrophilic contribution of increasing number of hydroxy groups, have limited solubility in water, which is inversely related to the melting point of the salt. The nature of this behavior is explained by the solid state structure, since these salts exist as ion-pairs, where hydroxy groups of each cation are strictly hydrogen bonded with the corresponding diclofenac anion: this structure in most cases originates high melting point and reduce solubility. Finally the diclofenac/N-pyrrolidine-ethanol salt forms hydrate polymorphs and has a complex behavior in the slid state, as a function of RU, temperature and pressure and also in its aqueous solutions. The formation of polymorphs is suspected also in the case of other three diclofenac salts, by the profile of DSC thermograms, at high temperature scanning.
| Titolo: | SOLUBILITY AND SOLID STATE STRUCTURE OF SOME DICLOFENAC SALTS |
| Autore/i: | FINI, ADAMO; Giuseppe Fazio; Laura Benetti |
| Autore/i Unibo: | |
| Anno: | 2005 |
| Titolo del libro: | Pharmaceutical Sciences Fair & Exhibition |
| Pagina iniziale: | 19 |
| Abstract: | Diclofenac, a non steroidal anti-inflammatory drug, is poorly soluble in water and exists as dimers in the solid state, bound together hydrogen bondings, involving the carboxylic groups, which are destroyed by the formation of a salt. Salts of alkaline metals are hydrate: their solubility in water is not so high as that of other sodium or potassium NSAID salts, and their behavior in water solution suggests self-aggregation. Salts formed with hydroxy aliphatic amines, despite the hydrophilic contribution of increasing number of hydroxy groups, have limited solubility in water, which is inversely related to the melting point of the salt. The nature of this behavior is explained by the solid state structure, since these salts exist as ion-pairs, where hydroxy groups of each cation are strictly hydrogen bonded with the corresponding diclofenac anion: this structure in most cases originates high melting point and reduce solubility. Finally the diclofenac/N-pyrrolidine-ethanol salt forms hydrate polymorphs and has a complex behavior in the slid state, as a function of RU, temperature and pressure and also in its aqueous solutions. The formation of polymorphs is suspected also in the case of other three diclofenac salts, by the profile of DSC thermograms, at high temperature scanning. |
| Data prodotto definitivo in UGOV: | 18-ott-2005 |
| Appare nelle tipologie: | 4.02 Riassunto (Abstract) |
File in questo prodotto:
Copyright © 2021