Conventional pharmaceutical forms allow a rapid and uncontrolled release of the active agent: the control of the release can be achieved by means of a suitable modifications either of the structure of the pharmaceutical form or of the physical state of the drug. The aim of this work was to prepare a form releasing an anti-pain drug: indomethacin as fast as possible. According to these ideas in this work we modified both the mentioned parameters inserting freeze-dried polymer/drug particles into microspheres, prepared by the ultrasonic spray-congealing technique, with the aim to modify the release of the drug.
Ultrasound spray-congealed and gastro-protected microspheres containing a co-freeze-dried PVP-indomethacin core.
CAVALLARI, CRISTINA;LUPPI, BARBARA;FINI, ADAMO;PASSERINI, NADIA;ALBERTINI, BEATRICE;RODRIGUEZ, LORENZO
2004
Abstract
Conventional pharmaceutical forms allow a rapid and uncontrolled release of the active agent: the control of the release can be achieved by means of a suitable modifications either of the structure of the pharmaceutical form or of the physical state of the drug. The aim of this work was to prepare a form releasing an anti-pain drug: indomethacin as fast as possible. According to these ideas in this work we modified both the mentioned parameters inserting freeze-dried polymer/drug particles into microspheres, prepared by the ultrasonic spray-congealing technique, with the aim to modify the release of the drug.File in questo prodotto:
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