Distant metastases represent a major step in progression and fatal outcome in canine and feline mammary carcinomas. Recent taxonomic advances portray the molecular features of mammary tumors that could allow targeted therapy in surgically unresectable sites. The molecular phenotypes, now in use in human medicine, are classified in two hormone (estrogen (ER) and/or progesterone (PR) receptor positive types (luminal A and luminal B ), and three hormone receptor negative (c-erbB-2 overexpressing, basal-like and normal-like). Since no data are yet available on the correlation between the molecular phenotypes of canine and feline mammary tumours and their lymph node and distant metastases, aim of the present study was to evaluate the molecular trend of cancer from its primary location to metastatic sites in three cats and two dogs with mammary tumors. Molecular phenotypes were determined immunohistochemically and an overall prevalence of c-erbB-2 overexpressing phenotype in the primary tumor (5 of 5 cases) and related lymph-node (3 of 4 cases) and distant metastases (10 of 11 metastatic sites) was the common finding. The latter result was not confirmed only in one metastatic site of two cases that had a shift towards a basal-like phenotype. This study confirmed the existence of both concordance and discordance in metastatic sites, although the prevalence of concordance supports the predictive therapeutic value based on the determination of the primary tumor phenotype.
Fenotipizzazione molecolare di metastasi sistemiche in tumori mammari di cagna e di gatta e valutazione della relazione con il fenotipo del relativo tumore primario e della metastasi linfonodale
MUSCATELLO, LUISA VERA;BEHA, GERMANA;BRUNETTI, BARBARA;BENAZZI, CINZIA;SARLI, GIUSEPPE
2013
Abstract
Distant metastases represent a major step in progression and fatal outcome in canine and feline mammary carcinomas. Recent taxonomic advances portray the molecular features of mammary tumors that could allow targeted therapy in surgically unresectable sites. The molecular phenotypes, now in use in human medicine, are classified in two hormone (estrogen (ER) and/or progesterone (PR) receptor positive types (luminal A and luminal B ), and three hormone receptor negative (c-erbB-2 overexpressing, basal-like and normal-like). Since no data are yet available on the correlation between the molecular phenotypes of canine and feline mammary tumours and their lymph node and distant metastases, aim of the present study was to evaluate the molecular trend of cancer from its primary location to metastatic sites in three cats and two dogs with mammary tumors. Molecular phenotypes were determined immunohistochemically and an overall prevalence of c-erbB-2 overexpressing phenotype in the primary tumor (5 of 5 cases) and related lymph-node (3 of 4 cases) and distant metastases (10 of 11 metastatic sites) was the common finding. The latter result was not confirmed only in one metastatic site of two cases that had a shift towards a basal-like phenotype. This study confirmed the existence of both concordance and discordance in metastatic sites, although the prevalence of concordance supports the predictive therapeutic value based on the determination of the primary tumor phenotype.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
