Chiral Perazamacrocycles: Synthesis and Applications. Part 1

Chiral non-racemic perazamacrocyles containing three or more nitrogen atoms in the form of different functions (amine, amide, imine) are prepared from optically active amines, diamines, -aminoacids, and their derivatives, by properly selected methodologies. The many applications of these optically pure perazamacrocycles rely on the basic and/or hydrogen bond donor properties of the nitrogen functions and include metal ions coordination, supramolecular chemistry, material science, molecular and enantioselective recognition, and asymmetric catalysis. Part 1 describes the preparation of polyamino, poly(amino-amido), polyamido macrocycles by procedures involving mainly nucleophilic substitution and acylation reactions, but also ring closing metathesis, multicomponent and click reactions in the cyclization step.