3,6-Disubstituted-1,2-diaminocycloexenes 5-7 are prepared by ring closing metathesis (RCM) reactions, catalysed by Grubbs’ ruthenium carbenecomplexes, of 4,5-diammino-3,6-disubstituted-1,7-octadienes 2, in turn available by the addition of allylic zinc reagents to the chiral diimine 1, by analogy with the previously described preparation of compounds 31and 42. Removal of the chiral auxiliary by hydrogenolysis affords the corresponding primary 1,2-diaminocyclohexanes.
C. Fiorelli, D. Savoia (2004). STEREOSELECTIVE SYNTHESIS OF 3,6-DISUBSTITUTED 1,2-DIAMINOCYCLOHEXANES BY RING CLOSING METATHESIS REACTIONS. CAMERINO : s.n.
STEREOSELECTIVE SYNTHESIS OF 3,6-DISUBSTITUTED 1,2-DIAMINOCYCLOHEXANES BY RING CLOSING METATHESIS REACTIONS
FIORELLI, CLAUDIO;SAVOIA, DIEGO
2004
Abstract
3,6-Disubstituted-1,2-diaminocycloexenes 5-7 are prepared by ring closing metathesis (RCM) reactions, catalysed by Grubbs’ ruthenium carbenecomplexes, of 4,5-diammino-3,6-disubstituted-1,7-octadienes 2, in turn available by the addition of allylic zinc reagents to the chiral diimine 1, by analogy with the previously described preparation of compounds 31and 42. Removal of the chiral auxiliary by hydrogenolysis affords the corresponding primary 1,2-diaminocyclohexanes.File in questo prodotto:
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