Bivalve molluscs, as Scapharca inaequivalvis, are filter-feeding organisms capable of bioconcentrating environmental chemical pollutants; consequently they are commonly used as bioindicators in the assessment of environmental quality. Of particular interest in this regard are the levels and the activities of enzymes involved in the xenobiotics detoxification such as MFO system, a multicomponent enzyme containing several forms of cytochrome P450, and the oxidative stress enzymes indirectly involved, such as the superoxide dismutase (SOD). Several studies carried out in fish and in marine invertebrate have demonstrated an inhibitory effect of TBT on different P450 isoforms. The aim of this work was to evaluate the effect of TBT on the content of P450 and on the activity and expression of MnSOD and CuZnSOD in a bivalve mollusc used as sentinel organism in the environmental pollution monitoring.
Monari M., Cattani O., Serrazanetti G.P., Andreani G., Gabbianelli R., Carpenè E. (2004). EFFECTS OF TRIBUTYLTIN ON THE MFO SYSTEM AND THE ANTIOXIDANT ENZYMES OF THE CLAM SCAPHARCA INAEQUIVALVIS. s.l : s.n.
EFFECTS OF TRIBUTYLTIN ON THE MFO SYSTEM AND THE ANTIOXIDANT ENZYMES OF THE CLAM SCAPHARCA INAEQUIVALVIS
MONARI, MARTA;CATTANI, OTELLO;SERRAZANETTI, GIAN PAOLO;ANDREANI, GIULIA;CARPENE', EMILIO
2004
Abstract
Bivalve molluscs, as Scapharca inaequivalvis, are filter-feeding organisms capable of bioconcentrating environmental chemical pollutants; consequently they are commonly used as bioindicators in the assessment of environmental quality. Of particular interest in this regard are the levels and the activities of enzymes involved in the xenobiotics detoxification such as MFO system, a multicomponent enzyme containing several forms of cytochrome P450, and the oxidative stress enzymes indirectly involved, such as the superoxide dismutase (SOD). Several studies carried out in fish and in marine invertebrate have demonstrated an inhibitory effect of TBT on different P450 isoforms. The aim of this work was to evaluate the effect of TBT on the content of P450 and on the activity and expression of MnSOD and CuZnSOD in a bivalve mollusc used as sentinel organism in the environmental pollution monitoring.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
