The oral supply of nutrients to growing animals is essential for the establishment and maintenance of a proper balance in the immune system, between regulator and effector functions. An adequate supply of nutrients is critical when intake is the limiting factor with respect to growth requirements, and when the immune system is challenged by new antigens. This is the case at weaning, particularly when subjects from different litters are mixed. In this light, the relevance of nutrients for innate and acquired immunity (humoral and cellular), and as vaccine adjuvants is reviewed. Some tools to assess in vivo and ex vivo the efficacy of nutrients are presented, with particular evidence for challenge models. Some attention has been paid to the effect of supplying nutrients above the standard requirements (for example the case of zinc as a growth promoter in piglet feeding), which allows maximum growth in a clean environment. In addition, some effects of molecules that are not considered essential, but nevertheless can have the role of nutrients in special phases of growth (nucleic acids, conjugated linoleic acid, precursors of glutathione etc.) are also discussed.

Immune response and nutrient intake

BOSI, PAOLO;TREVISI, PAOLO
2006

Abstract

The oral supply of nutrients to growing animals is essential for the establishment and maintenance of a proper balance in the immune system, between regulator and effector functions. An adequate supply of nutrients is critical when intake is the limiting factor with respect to growth requirements, and when the immune system is challenged by new antigens. This is the case at weaning, particularly when subjects from different litters are mixed. In this light, the relevance of nutrients for innate and acquired immunity (humoral and cellular), and as vaccine adjuvants is reviewed. Some tools to assess in vivo and ex vivo the efficacy of nutrients are presented, with particular evidence for challenge models. Some attention has been paid to the effect of supplying nutrients above the standard requirements (for example the case of zinc as a growth promoter in piglet feeding), which allows maximum growth in a clean environment. In addition, some effects of molecules that are not considered essential, but nevertheless can have the role of nutrients in special phases of growth (nucleic acids, conjugated linoleic acid, precursors of glutathione etc.) are also discussed.
2006
Biology of Nutrition in Growing Animals
343
363
Bosi P.; Trevisi P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/15403
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